The People of Tulane Cancer Center Research
Asim B. Abdel-Mageed, D.V.M., Ph.D.
Dr. Abdel-Mageed became a research instructor of pharmacology in 1996, continuing his training in molecular cancer pharmacology. He studied genes associated with breast cancer cell growth and their interaction with nuclear transcription factors to mediate mitogenic responses. In 1997, Dr. Abdel-Mageed joined the faculty as an assistant professor in the Department of Urology and adjunct assistant professor of pharmacology. He is founding director of the Molecular Oncology Research Laboratories in the Department of Urology. He has over 60 peer-reviewed publications and over 100 presentations at national and international meetings. Dr. Abdel-Mageed has served on several National Institutes of Health (NIH), Department of Defense (DOD), and a number of international grant review panels (e.g. Qatar National Foundation, Italian Academy of Sciences, Singapore Medical Research Council, etc.). Additionally, Dr. Abdel-Mageed has been a mentor (for junior faculty members, graduate and undergraduate) at Tulane and other institutions and has participated on many research advisory boards for many U.S. institutions, such as Xavier University of Louisiana, Tuskegee University and Jackson State University.
Funded (~ $8 million) through federal (NIH/DOD) and private foundations (ASC), Dr. Abdel-Mageed's laboratory primarily focuses on basic research into the cellular and molecular aspects of urologic diseases, with particular attention given to prostate and bladder cancer. The laboratory has a special interest in identifying molecular determinants of prostate and breast cancer progression using in vitro and in vivo experimental approaches. Dr. Abdel-Mageed's laboratory has been conducting studies pertaining to isolation and characterization of in vivo differentially expressed genes of prostate cancer as they relate to age, race and tumor grade. Using cutting-edge technology of laser capture microdissection, suppressive subtractive hybridization, and custom cDNA microarray on fresh prostate specimens, his lab was able to isolate and characterize a selective subset of race-, and prostate tumor-specific nuclear matrix (NM) genes. One area of interest Dr. Abdel-Mageed is particularly focused on is unraveling the mechanisms of nuclear matrix proteins in prostate cancer progression, with special emphasis on their potential role in the disproportionate incidence and mortality of prostate cancer among African American men. Functional analysis of the differentially expressed NM genes should allow for more in-depth understanding of the underlying mechanisms regulating growth and metastasis of prostate cancer in African American men.
Dr. Abdel-Mageed’s laboratory is conducting DoD-funded research aimed at targeting “intracrine” production of androgens by prostate cancer cells at their sanctuary metastatic bone sites. To this end, one of his studies, recently funded by the NIH and DOD, is to assess the efficacy of genetically engineered adipose tissue-derived stem cells to eliminate androgen production and action on bone metastatic prostate cancer cells. The ultimate goal is to examine their effectiveness as an adjuvant approach to mainstay androgen deprivation therapy in a preclinical animal model and a clinical setting.
More recently, Dr. Abdel-Mageed's laboratory has discovered a novel role for tumor-derived exosomes in neoplastic reprogramming of mesenchymal stem cells, thereby potentiating clonal expansion of tumor cells at their primary and metastatic sites. This new concept attracted funding ($4.2 million) from the NIH/National Center for Advancing Translational Sciences (NCATS). The objective is to target tumor-derived exRNA-containing microvesicles by high throughput screening of ~ 4,000 human approved drugs. The ultimate goals is to reposition FDA approved drug(s) to inhibit biogenesis/release of exosomes by tumor cells and/or their uptake by recipient cells to reduce or circumvent tumor growth in cancer patients. More details on this grant can be retrieved from the NIH press release - http://projectreporter.nih.gov/project_description.cfm?projectnumber=1UH2TR000928-01.
Zakaria Y. Abd Elmageed, Krzysztof Moroz, Sudesh K. Srivastav, Zhide Fang, Byron E. Crawford, Krishnarao Moparty, Raju Thomas, and Asim B. Abdel-Mageed. High circulating estrogens and selective expression of ERβ in prostate tumors of African Americans: Implications for racial disparity of prostate cancer. Carcinogenesis. 2013 May 8. [Epub ahead of print] 2013. PMID: 23658372
Hogyoung Kim, Zakaria Y. Abd Elmageed, Jihang Ju, Amarjit S. Naura, Asim B. Abdel-Mageed, Shibu Varughese, Dennis Paul, Suresh Alahari, Andrew Catling; Jong G. Kim; and A. Hamid Boulares. PDZK1 is a novel factor in breast cancer that is indirectly regulated by estrogen through IGF-1R and promotes estrogen-mediated growth. Mol. Med. 19(1):253-62, 2013. PMID: 23821363
Emad Kandi, Koji Tsumagari, Jingjing Ma, Zakaria Abd Elmageed, Xinying Li, Douglas Slakey, Debasis Mondal, Asim B Abdel-Mageed. Synergistic inhibition of thyroid cancer by suppressing MAPK/PI3K/AKT pathways. J. Sur. Res., 2013 Apr 2. [Epub ahead of print], PMID: 23602735
Limin Ma, Yijun Yang, Suresh C. Sikka, Philip J. Kadowitz, Louis J. Ignarro, Asim B. Abdel-Mageed**, and Wayne J.G**. Hellstrom. Adipose tissue derived stem cell-seeded small intestinal submucosa for tunica albuginea grafting and reconstruction. Proc. Natl. Acad. Sci., USA, 7;109(6):2090-5, 2012. PMID: 22308363 **joint senior author.
Qiuyang Zhang, Sen Liu, Dongxia Ge, Qingsong Zhang, Yun Xue, Zhenggang Xiong, Asim B. Abdel-Mageed, Leann Myers, Steven M. Hill, Brian G. Rowan, Oliver Sartor, Prescott L. Deininger, Jonathan Melamed, Zhenbang Chen, and Zongbing You. Interleulin-17 promotes formation and growth of prostate adenocarcinoma in mouse. Cancer Res., 2012, PMID: 22461511.
M. Mansour, D. Schwartz, Robert Judd, B. Akingbemi, T. Branden, J. Dennis, F. Bartoli, A. Hazi, I. Napier, and A. B. Abdel-Mageed. Thiazolidinediones/PPARÁ agonists and fatty acid synthase inhibitors as an experimental combination therapy for prostate cancer. Int. J. Oncol., 2011 Feb;38(2):537-46. PMID: 21170507
J. Ju, A.S. Naura, .Y Errami; M. Zerfaoui, H. Kim, J.G. Kim, Z.Y. Abd Elmageed, A.B. Abdel-Mageed, C. Giardina, A. A. Beg, M. E. Smulson, and A. H. Boulares. Phosphorylation of p50 NF-κB at a single serine residue by DNA-dependent protein kinase is critical for VCAM-1 expression upon TNF Treatment. J. Biol. Chem., 2010 Dec 24;285(52):41152-60. [Epub ahead of print] PMID: 20966071.
Tisheeka R. Graham, Krishna C. Agrawal, A. B. Abdel-Mageed. Independent and cooperative roles of TNF-α, NF-κB, and BMP-2 in regulation of metastasis and osteomimicry of prostate cancer cells and differentiation and mineralization of MC3T3-E1 osteoblast-like cells. Cancer Science, 101(1):103-11, 2009. PMID: 19811499.
Tisheeka Graham, Valerie Odero-Marah, Leland WK Chung, Krishna C. Agrawal, and Asim B. Abdel-Mageed. PI3K/Akt-Dependent Transcriptional Regulation and Activation of BMP-2-Smad Signaling by NF-κB in Metastatic Prostate Cancer Cells. Prostate, 69:168-80, 2008. PMID: 18942118
Promil Kukreja, Asim B. Abdel-Mageed, Debasis Mondal, Krishna C. Agrawal. SDF-1α up-regulates expression of the chemokine receptor CXCR4 in PC3 cells via a MEK-ERK dependent NF-κB activation. Cancer Res. 1;65(21):9891-8, 2006.
Rodney Davis, Dingwu Jia, Bekir Cinar, Suresh. C. Sikka, Krishnarao Moparty, Haiyen E. Zhau, Leland W. Chung, Krishna.C. Agrawal and A. B. Abdel-Mageed. Functional androgen receptor confers sensitization of androgen independent prostate cancer cells to anticancer therapy via caspase activation. Biochem. Biophy. Res. Commun., 309:937-45, 2003.
Vincent Flynn, Jr., Anshiya Ramanitharan, Krishnaro Moparty, Rodney Davis, Suresh Sikka, Krishna C. Agrawal, A. B. Abdel-Mageed. Adenovirus-mediated inhibition of NF-κB conferschemosensitization and apoptosis in prostate cancer cells. Int. J. Oncol., 23: 317-323, 2003.
Andrew Nguyen, Z. Jing, S. Mahoney, Rodeny Davis, Suresh C. Sikka, Krishna C. Agrawal and Asim B. Abdel-Mageed:. In vivo gene expression profile analysis of metallothionein in renal cell carcinoma. Cancer Lett, 160:133-140, 2000.
A. B. Abdel-Mageed and Krishna C. Agrawal: Activation of NF-kappa B: potential role in metallothionein-mediated mitogenic response. Cancer Res., 58:2335-2338, 1998.
A. B. Abdel-Mageed and Krishna C. Agrawal. Antisense down-regulation of metallothionein induces growth inhibition and apoptosis in human breast carcinoma MCF7 cells. Cancer Gene Therapy. 4:199-207, 1997.
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