The People of Tulane Cancer Center Research
Asim B. Abdel-Mageed, D.V.M., Ph.D.
Dr. Abdel-Majeed is founding director of the Molecular Oncology Research Laboratories in the Department of Urology. He has over 25 peer-reviewed publications and has served on several DOD grant review panels. Dr. Abdel-Mageed's laboratory primarily focuses on basic research into the cellular and molecular aspects of urologic diseases, with particular attention given to prostate and bladder cancer. The laboratory has a special interest in tumor cell invasion, metastasis, and disease progression. Molecular biology, genetics, cell biology, and biochemical techniques, as well as studies involving transgenic TRAMP mouse model and in situ analysis of human tissues, are routinely employed to address questions concerning these issues.
One area of major interest to Dr. Abdel-Mageed is the role of metallothionein in prostate cancer progression, with special emphasis on cell proliferation using antisense technology and on expression of invasion, angiogenesis and metastasis-related genes using in vitro and in vivo xenograft model systems. He is also examining their expression profile in situ to evaluate their correlation with tumor grade and their potential use as biomarkers for disease progression.
More recently, his laboratory has been conducting studies pertaining to isolation and characterization of in vivo differentially expressed genes of prostate cancer as they relate to race, age, and tumor grade using state-of-the-art laser capture microdissection, suppressive subtractive hybridization and DNA microarray technology. Analysis of the expression and function of these genes should allow for a more in depth understanding of the processes controlling prostate cancer cell growth, invasion, and metastasis.
Dr. Abdel-Mageed's research interests also include dissection of molecular mechanisms and signaling pathways associated with chemo/radioresistance of prostate cancer. Using a super-repressor I kappa B adenoviral delivery approach, his laboratory is conducting experiments to evaluate the role of inhibiting the activation of the nuclear factor NF-kappa B in enhancing radio/chemosensitization and apoptosis of prostate cancer cells.
Tisheeka R. Graham, Krishna C. Agrawal, A. B. Abdel-Mageed. Independent and cooperative roles of TNF-alpha, NF-kappa B, and BMP-2 in regulation of metastasis and osteomimicry of prostate cancer cells and differentiation and mineralization of MC3T3-E1 osteoblast-like cells. Cancer Science, 2009 Sep 9. [Epub ahead of print].
X. Zeng, S.C. Sikka, L. Huang, C. Sun, C. Xu, D. Jia, A. B. Abdel-Mageed, J.E. Pottle, J.T. Taylor and M. Li. Novel role for the transient receptor potential channel TRPM2 in prostate cancer cell proliferation. Prostate Cancer and Prostatic Dis. (2009), 1–7 (2009).
Tisheeka Graham, Valerie Odero-Marah, Leland WK Chung, Krishna C. Agrawal, and Asim B. Abdel-Mageed. PI3K/Akt-Dependent Transcriptional Regulation and Activation of BMP-2-Smad Signaling by NF-kB in Metastatic Prostate Cancer Cells. Prostate, 69:168-80, 2008.
Promil Kukreja, Asim B. Abdel-Mageed, Debasis Mondal, Krishna C. Agrawal. SDF-1α up-regulates expression of the chemokine receptor CXCR4 in PC3 cells via a MEK-ERK dependent NF-κB activation. Cancer Res. 1;65(21):9891-8, 2006.
Rodney Davis, Dingwu Jia, Bekir Cinar, Suresh. C. Sikka, Krishnarao Moparty, Haiyen E. Zhau, Leland W. Chung, Krishna.C. Agrawal and A. B. Abdel-Mageed. Functional androgen receptor confers sensitization of androgen independent prostate cancer cells to anticancer therapy via caspase activation. Biochem. Biophy. Res. Commun., 309:937-45, 2003.
Vincent Flynn, Jr., Anshiya Ramanitharan, Krishnaro Moparty, Rodeny Davis, Suresh Sikka, Krishna C. Agrawal, A. B. Abdel-Mageed. Adenovirus-mediated inhibition of NF-kB conferschemosensitization and apoptosis in prostate cancer cells. Int. J. Oncol., 23: 317-323, 2003.
A.B. Abdel-Mageed, Fusheng Zhao, Barbra Rider and Krishna.C. Agrawal. Erythropoeitin-induced metallothionien gene expression: role in proliferation of K562 cells. Exp. Biol. Med., 228:1033-39, 2003.
M.A. Eid, R.W. Lewis, Asim B. Abdel-Mageed and M.V. Kumar. Reduced response of prostate cancer cells to TRAIL is modulated by NF-kappa B-mediated inhibition of caspases and Bid activation. Int. J. Oncol., 21(1):111-7, 2002.
Andrew Nguyen, Z. Jing, S. Mahoney, Rodeny Davis, Suresh C. Sikka, Krishna C. Agrawal and Asim B. Abdel-Mageed: In vivo gene expression profile analysis of metallothionein in renal cell carcinoma.. Cancer Lett, 160:133-140, 2000.
A. B. Abdel-Mageed and Krishna C. Agrawal: Activation of NF-kappa B: potential role in metallothionein-mediated mitogenic response. Cancer Res., 58:2335-2338, 1998.
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