The People of Tulane Cancer Center Research
Anil Mishra, Ph.D.
Dr. Mishra's research established that eosinphils are the resident cells of the gastrointestinal tract that home prenatally (Mishra et al., J. Clin. Invest. 1999, 103, 1719-27). He showed that eosinophil active chemokine eotaxin-1 constitutively expressed in the gastrointestinal tract (esophagus to colon) and eosinophils homing into the gastrointestinal tract is dependent on eotaxin-1. He developed the first murine model of eosinophilic esophagitis (EoE) (Mishra et al., J. Clin. Invest. 2001, 107, 83-90). His findings implicated aeroallergen in the etiology of EoE and suggested that esophageal eosinophilic inflammation is mechanistically associated with pulmonary inflammation (Mishra et al., J. Immunology 2002, 168, 2464-69 and Gastroenterology, 2003, 125, 1419-27). His current research interests are focused on the role of IL-15 and IL-18 in pulmonary and gastrointestinal eosinophilic inflammation and his findings indicate that rIL-15 is a therapeutic molecule for allergen-induced airway hyperactivity and fibrosis for chronic asthma and other pulmonary functional impairment. Currently, his work also indicates that resistin family of molecule (RELM)-alpha overexpression in the lung promotes lung and esophageal epithelial cell proliferation and promotes lung adenocarcinoma following secondary stimulation.
Dr. Mishra is an elected fellow of the American Academy of Allergy Asthma Immunology (FAAAAI) and the American Gastrointestinal Association (FAGA). He has published over 65 articles, book chapters and reviews on molecular mechanisms of pulmonary and gastrointestinal toxicity and allergic responses in high impact factor journals. Some of his publications have been cited more than 300 to 400 times (through 2013). The National Institutes of Health via NIDDK and NIAID institutes have supported Dr. Mishra’s research into the mechanisms that induce EoE, and he is a reviewer of a number of NIH study sections.
Mishra A, Dayal N, Beck-Speir I. Effect of sulfite on oxidative metabolism of neutrophils: Studies with lucigenin and luminol dependent chemiluminescence. J Biolumin Chemilumin 1995; 10:9-19.
Mishra A, Liu J-Y, Brody AR, Morris GF. Inhaled asbestos fibers induced p53 expression in rat lung. Am J Respir Cell Mol Biol 1997; 16:479-485.
Mishra A, Hogan SP, Lee, JJ, Foster PS, Rothenberg ME. Fundamental signals regulating eosinophil homing into the gastrointestinal tract. J Clin Invest 1999; 103:1719-1727.
Mishra A, Doyel N, Martin WJ. Bleomycin –mediated pulmonary toxicity: evidence for a p53-mediated response. Am J Respir Cell Mol Biol, 2000; 22:543-549.
Hogan SP, Mishra A, Brandt E, Foster PS, Rothenberg ME. A critical role for eotaxin in experimental oral antigen-induced eosinophilic gastroenteritis, Proc Natl Acad Sci USA, 2000; 97:6681-6686.
Mishra A, Hogan SP, Brandt E, Rothenberg ME. Peyer’s patch eosinophils: identification, characterization, and regulation by mucosal allergen exposure, interleukin-5, and eotaxin, Blood, 2000; 96:1538-1544.
Mishra A, Beck D, Weaver T, Rothenberg ME. Allergic airway inflammation inhibits the human surfactant protein C promoter in transgenic mice, J Biol Chem, 2001; 276:8453-8459.
Mishra A, Hogan SP, Brandt E, Rothenberg ME. An etiological role for aeroallergens in experimental esophagitis, J Clin Invest, 2001; 107:83-90.
Hogan SP, Mishra A, Brandt EB, Royalty MP, Pope SM, Zimmermann N, Foster PS, Rothenberg ME. A pathological role for eotaxin and eosinophils in experimental oral antigen induced eosinophilic gastrointestinal inflammation, Nature Immunol, 2001; 2:353-360.
Rothenberg ME, Mishra A, Brandt EB, Hogan SP. Gastrointestinal Eosinophils in Health and Disease. Advances in Immunology, 2001; 78:291-328.
Rothenberg ME, Mishra A, Brandt EB, Hogan SP. Gastrointestinal Eosinophils. Immunological Reviews, 2001; 179:139-155.
Mishra A, Hogan SP, Brandt EB, Wagner, N, Crossman MW, Foster PS, Rothenberg ME. Enterocyte expression of the eotaxin and interleukin-5 transgenes induces compartmentalized dysregulation of eosinophil trafficking. J Biol Chem, 2002; 277: 4406-4412.
Mishra A, Hogan,SP, Brandt,E and Rothenberg ME. Interleukin-5 promotes eosinophil trafficking to the esophagus, J Immunol, 2002, 168:2464-2469.
Mishra A, Rothenberg ME. Intratracheal IL-13 induces eosinophil esophagitis is regulated by IL-5, eotaxin-1 and STAT6. Gastroenterology. 2003;125(5):1419-27
Blanchard C, Wang N, Stringer KF, Mishra A, Fulkerson PC, Abonia JP, Konikoff MR, Collins MH, Cohen MB, Akers R, Hogan SP, Assa'ad AH, Putnam PE, Aronow BJ, Rothenberg ME. 2006. Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. J Clin Invest. 116(2):536-547.
Mishra A, Schlotman J, Wang M and Rothenberg ME. 2006. Critical role for T cell immunity in experimental eosinophilic esophagitis in mice. J. Leukocyte Biology.81, 916-924
Mishra A, Wang M, Pemmaraju VR, Collins MU, Putnam PE and Marc Rothenberg 2008. Esophageal remodeling develops as a consequence of tissue specific IL-5 induced eosinophilia. Gastroenterology. 134: 204-214
Zhu X, Wang M, Crump C and Mishra A. 2009. An imbalance of esophageal effector and regulatory T cell subsets in experimental eosinophilic esophagitis. AJP-Gastroenterology Liver Physiol. 297, 550-558
Madhavi R, Mavi P, Zhu X, Abonia JP, Rothenberg ME, and Mishra A. 2010 Indoor insect allergens are potent inducer of eosinophilic esophagitis, J. Leukocyte Biol 88 (2):337-46
Zhu, X., M. Wang, P. Mavi, M. Rayapudi, A. K. Pandey, A. Kaul, P. E. Putnam, M.E. Rothenberg, and Mishra. A 2010 Interleukin-15 Expression Is Increased in Human Eosinophilic Esophagitis and Mediates Pathogenesis in Mice. Gastroenterology. 139: 182-192
Rayapudi M, N. S., Rajavelu P, Moffitt M, Mishra A, Akhilesh Pandey and Mishra A. 2012. Significance of esophageal local lymph nodes in food allergen-induced iNKT cell-mediated experimental eosinophilic. AJP-Gastroenterology & Liver Physiol. 302, G645-654, first on line published Dec 29, 2011
Parm Mavi, Priya Rajavelu, Madhavi Rayapudi, Richard Paul and Mishra A. 2012 Esophageal functional impairments in experimental eosinophilic esophagitis. AJP Gastroenterology & Liver Physiol 302, G1347-1355
Rituraj Niranjan, Madhavi Rayapudi, Akanksha Mishra, Scott Dynda and Mishra A. 2013. Pathogenesis of allergen-induced eosinophilic esophagitis is independent to Interleukin (IL)-13. Immunology and Cell Biology. 91, 408–415; doi:10.1038/icb.2013.21; published online 21 May 2013
Madhavi, R, Rajavelu P. Zhu X, Mattner J, Kaul A, and Mishra A. Invariant natural killer T cells neutralization is a possible novel therapy for human eosinophilic esophagitis Clinical and Translational Immunology, 2014:3, 1-11
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