Tulane Cancer Center

 Donald J. Krogstad, M.D.
Henderson Professor and Chairman of Tropical Medicine
Director of the Center for Infectious Diseases
TCC Contributing Member
krogstad@tulane.edu
(504) 988-3558, (504) 988-6686 fax
1430 Tulane Ave., Box SL-17, New Orleans, LA 70112-2699

Biographical Narrative:
Dr. Krogstad received his undergraduate degree from Bowdoin College in Brunswick, Maine. He received his M.D. in 1969 from Harvard Medical School. After training at the Massachusetts General Hospital in Boston, he served at the Centers for Disease Control in Atlanta in Parasitic Diseases and as a Peace Corps Volunteer Physician in Lilongwe, Malawi. After serving at the Washington University School of Medicine for 14 years, Dr. Krogstad joined the Tulane faculty in June 1992 as Chair of Tropical Medicine, was invested as the Henderson Professor in 1994, and appointed Director of the Center for Infectious Diseases in 1998. Dr. Krogstad's current research is aimed at the molecular and genetic bases of resistance to chloroquine and quinine, structure-activity relationships among antimalarials, the development of a transfection system in Plasmodium falciparum and the use of plasmid constructs with a proline-rich amino acid linker to enhance the immunogenicity of cloned malaria parasite antigens. Field studies are centered in Mali and focus on three issues: optimal strategies for the use of chloroquine, techniques for the characterization of individual clones from polyclonal field isolates, and the development of methods to study pathogenicity and parasite virulence.

Selected Publications:

• De D, Krogstad FM, Cogswell FB, Krogstad DJ. Aminoquinolines that circumvent resistance in P. falciparum in vitro. Am J Trop Med Hyg 55: 579-583 (1996)
• Davison BB, Cogswell FB, Baskin GB, Falkenstein KP, Henson EW, Taranta AF, Krogstad DJ. Plasmodium coatneyi in the rhesus monkey (Macaca mulatta) as a model of malaria in pregnancy. Am J Trop Med Hyg 59: 189-201 (1998)
• Masinde GL, Krogstad DJ, Gordon DM, Duffy PE.Immunization with SPf66 and subsequent infection with homologous and heterologous parasites. Am J Trop Med Hyg 59: 600-605 (1998)
• De D., Krogstad FM, Byers LD, Krogstad DJ.Structure-activity relationships (SARs) for antiplasmodial activity among 7-substituted-4-aminoquinolines. J Med Chem 41: 4918-4926 (1998)
• Davison, B.B., Cogswell FB, Baskin GB, Falkenstein KP, Henson EW, Krogstad DJ. Placental changes associated with fetal outcome in the Plasmodium coatney/rhesus monkey model of malaria in pregnancy. Am J Trop Med Hyg 63:158-173 (2000)
• Doumbia S, Brown C, Doumbo O, Bagayoko M, Regens JL, Poudiougou B, Dicko A, Touré YT, Krogstad DJ. Cluster analysis of cerebral malaria and entomologic inoculation rates based on GIS/GPS data in the village of Bancoumana. Am J Trop Med Hyg (in press) (2002)