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 Peter Didier    

Peter Didier, PhD
Veterinary Pathologist
Department of Tropical Medicine
Tulane University School of Public Health and Tropical Medicine
1440 Canal Street
New Orleans, LA 70112
Phone: (504) 988-8936
Fax: (504) 988-7313
pjdidier@tulane.edu

 




Research Interests:

TB diagnosis, vaccines, and pathogenesis; West Nile virus pathogenesis; microsporidiosis drug testing model


Educational Background:

  • PhD, University of Illinois, Chicago, Illinois
  • DVM, The Ohio State University, Columbus, Ohio
  • BS, Western Kentucky University, Bowling Green, Kentucky

 

Selected Publications:

 

Liu DX, Doyle LA, Bouljihad MT, Didier PJ, Gilbert MH, Wang X, Pahar B, Bohm RP, Veazey RS, Lackner AA. Locally infiltrative ameloblastic fibroma in a rhesus macaque (Macaca mulatta) with characterizations of its proliferating activity and biological behavior. J Vet Diagn Invest. 2012 May;24(3):630-5. doi: 10.1177/1040638712443359.

C. Mason, Didier P, Xie J, Kolls J, Summer WS, Nelson S, Greenberg SS. Alcohol inhibits Mycobacteria tuberculosis-induced alveolar macrophage mRNA for nitric oxide synthase in vitro. [ABSTRACT #2088]. FASEB J 1994, 8(4):A361.

Didier PJ, Didier ES, Murphey-Corb M. Experimental microsporidiosis in immunodeficient monkeys. [ABSTRACT 5614]. FASEB J 9(4):A967, 1995.

Greenberg SS, Xie JM, Kolls J, Mason C, Didier P. Rapid induction of mRNA for nitric oxide synthase II in rat alveolar macrophages by intratracheal administration of Mycobacterium tuberculosis and Mycobacterium avium. Proc Soc Exp Bio Med, 209:46-53, 1995.
Scollard DM, Didier PJ, Dietrich MA, Bohn Jr RP. Selective increases in CD45RO(+) CD 38(+) T cells in 1E and 2E responses to BCG in rhesus macaques. [Abstract]. Proc of 9th Inter Immunol Congress, San Francisco,CA, July 23-29, 1995.

Didier PJ, Campeau RJ, Cogswell FB, Blanchard JL, Bohm RP, Ratteree MS, Peyman CA, Spurlock JP, Dupepe L, Krogstad FM, Collins WE, Krogstad DJ. Myocardial sequestration in rhesus monkeys infected with Plasmodium fragile. [ABSTRACT 545]. Amer Soc Trop Med Hygiene 53(2):267, 1995.

Scollard DL, Didier PJ, Bohn RP. A method to assess changes in rhesus lymphatic T cells in vivo during local immune responses.[ABSTRACT]. Second Ann Molecular Biology and Biotechnology Conference, Baton Rouge, LA, Feb 9-10, 1996.

Didier P, Ramesh G, Newman G, Maslow J. Detection of M. avium by PCR in rhesus monkeys. [ABSTRACT #2486]. FASEB J, 10(6):A1431, 1996.

Mankowski JL,Flaherty MT, Spelman JP, Hauer DA, Didier PJ, Amedee AM, Murphey-Corb M,Kirstein LM, Munoz A, Clements JE, Zink MC. Pathogenesis of simian immunodeficiency virus encephalitis: viral determinants of neurovirulence. J Virol, 71(8):6055-6060, 1997. 9. Ribbons KA, Currie MG, Connor JR, Manning PT, Allen PG, Didier P, Ratterree S, Clark DA, Miller MJS. The effect of inhibitors of inducible nitric oxide synthase on chronic colitis in the rhesus monkey. J Pharmacol Exptl Therap, 280(2):1008-1015, 1997.

Newman MJ, Todd, CW, Lee EM, Balusubramanian M, Didier PJ, Katz JM. Increasing the immunogenicity of a trivalent influenza vaccine with adjuvant-active nonionic coplolymers for potential use in the elderly. Mechanisms of Aging and Development 93:189-203, 1997.

Brar I, Didier P, Murphey-Corb M, Maslow JN. Epidemiology of Mycobacterium avium complex (MAC) infection in simian immunodeficiency virus (SIV) infected rhesus monkeys. [ABSTRACT], 4th Conf Retroviruses and Opportunistic Infections, Oct,1996.

Didier PJ, Didier ES, Snowden K, Shadduck JA. Encephalitozoonosis, in Infectious Diseases of the Dog and Cat, CE Greene (ed), 2nd edition, W.B. Saunders, Orlando, FL, pp 465-470, 1998.

Grab DJ, Didier PJ, Chesney J, Givens C, Kennedy R, Lanners N, Martin L, Bucala R. Borrelia burgdorferi bind to peripheral blood fibrocytes: Leukocyte-like cells with potential for connective tissue targeting. [ABSTRACT #672]. FASEB J 11(3):A115, 1997.

Didier PJ an Gladue R. Cellular response to chemokines in skin of rhesus monkeys. [ABSTRACT #674] FASEB J 11(3):A115, 1997.
Miller MJS, Ribbons KA, Didier P, Krowicka H, Clark DA, Mannick EE. Endotoxin tolerance is evident in colonic explants from rhesus colitis or rat TNBS colitis: Therapeutic implications. [ABSTRACT]. Amer Gastroenterological Assoc and Amer Assoc for Study of Liver Diseases, May 11-14, 1997.

Zink MC, Amedee AM, Mankowski JL, Craig L, Didier P, Carter, Munoz A, Murphey-Corb M, Clements JE. Pathogenesis of SIV Encephalitis, Selection and replication of neurovirulent SIV. Amer J Path 151(3):793-803, 1997.

Didier PJ, Blanchard JL, Gormus BJ. Pulmonary tuberculosis in normal rhesus monkeys infected with Mycobacterium tuberculosis H37Rv. [ABSTRACT] ASTMH, Dec 7-11, 1997.

Green LC, Didier PJ, Didier ES. Analysis of percoll gradient fractions from culture supernantants of the microsporidian, Encephalitozoon cuniculi. [ABSTRACT #626]. Amer Soc Trop Med Hygiene, Dec 7-11, 1997.

Didier PJ, Blanchard JL. Chronic tuberculosis produced by low dosage of M. tuberculosis (Erdman) in rhesus monkeys. [ABSTRACT# 734]. ASTMH 59(3):361, 1998.

Green LC, Rogers LB, Didier PJ, Didier ES. E. bieneusi infection in immunocompromised rhesus monkeys. [ABSTRACT #644]. ASTMH 59(3):332, 1998.

Handali S, Krogstad FM, Phillips J, Didier PJ, Cogswell FB, Krogstad DJ. Cytoadherence of Plasmodium knowlesi-infected red blood cells (RBCs) to rhesus brain endothelium cells. [ABSTRACT #372]. ASTMH 59(3):238,1998.

Colberg A, Frazine R, Sampson K, Villarraga ML, Didier PJ. Mechanical properties of rhesus femoral bone as determined by three-point bending and ultrasound tests. [ABSTRACT]. FASEB J, 1999.

Villarraga ML, Aitken E, Colberg A, Pope R, Didier P. Mechanical behavior of rhesus monkey lumbar vertebrae as a model for osteoporosis. [ABSTRACT]. FASEB J, 1999.

Didier PJ, Paradis TJ, Gladue RP. The CC chemokine MIP-1" induces a selective monocyte infiltration following intradermal injection into nonhuman primates. Inflammation 23(1):75-86, 1999.

Newman GW, Adams DL, Maslow JN, Murphey-Corb M, Didier PJ. Differential tumor necrosis factor-" production in simian immunodeficiency virus-infected rhesus macaques co-infected with Mycobacterium avium. Clin Infect Dis 28:514-519, 1999.

Green, LC, Didier PJ, and Didier ES.1999. Fractionation of sporangial stages of the microsporidian Encephalitozoon cuniculi by Percoll grandients. J Euk Microbiol 46:434-438.

Fortgang IS, Didier PJ, and Levy LS. B-cell leukemia in a rhesus macaque (Macaca mulatta) infected with simian immunodeficiency virus. Leukemia and Lymphoma 37(5-6):657-662, 2000.

Villarraga ML, Pope RL, Aitken E, Rice J, Didier P. Evaluation of compositional and structural changes in female rhesus monkey lumbar cancellous bone as a potential model for aging. [ABSTRACT], Orthopaedic Research Society, 46th Annual Meeting, Orlando, FL Mar 12-15, 2000.

Didier ES, Nasr M, LeBlanc PJ, Bertucci DC, Phillips J, Didier PJ. 2000. Antimicrosporidial effects of the sesquiterpenes, fumagillin, TNP-470, and eight ovalicin derivatives in vitro and in vivo. [ABSTRACT 262] Seventh Conference on Retroviruses and Opportunistic Infections. San Francisco, CA Jan 30- Feb 2.PHS 398

Didier Peter J., Blanchard James L. Chronic disease produced by two strains of Mycobacterium tuberculosis in rhesus monkeys. [ABSTRACT 521] Amer Soc Trop Med Hygiene 62(3):356, 2000.
Handali S, Cogswell FB, Sumpter M, Lanclos C, Martin LN, Krogstad FM, Phillips J, Didier PJ, Krogstad DJ. ICAM-1 upregulation in TNF-treated brain endothelial cells from rhesus monkeys.[ABSTRACT 655] Amer Soc Trop Med Hygiene 62(3):413, 2000.

Didier PJ, Phillips JN, Bertucci, Kuebler DJ, Nasr M, Didier ES. Evaluation of therapies in Microsporidia-infected athymic mice. [ABSTRACT] Amer Soc Microbiol, 2001.

Handali S, Cogswell FB, Sumpter ML, Lasater BL, Dennis V, Didier PJ, Phillips J, Krogstad DJ. Reduced TNF and TNF responses (NF-kB, mRNA for ICAM-1, ICAM-1 expression)in monkeys with malaria. [ABSTRACT] Amer Soc Trop Med Hygiene 2001.

Didier ES, Bertucci DC, Green LC, Stovall ME, Didier PJ. Encephalitozoon cuniculi infection in mice with the chronic granulomatous disease (CGD) disorder. J Eukaryotic Micro 2001, 48:79-80S.

Didier ES, Green LC, Stovall ME, Didier PJ. Microsporidiosis: An opportunistic and emerging infection. [ABSTRACT] V Congreso Centroamericano de Parasitologia Y Medicina Tropical VII Curso International de Enfermedades Infecciosas, I Congreso Nacional de Parasitologia, 6-10, agosto, 2001, Tegucigalpa, Honduras, Centroamerica.

Didier PJ, Blanchard JL, Gormus B. Pathology of SIV/TB Coinfection in Rhesus Monkeys. [ABSTRACT #8219] FASEB J, 2002.

Stacey Tate, Peter Didier, Mark Newman and Gale Newman. Evaluation of a Copolymer/HIV Protein Subunit Vaccine Formulation in Rhesus Macaques.[ABSTRACT] FASEB J 2002.

Maslow JN, Brar I, Smith G, Newman GW, Mehta R, Thornton C, Didier P. Latent infection as a source of disseminated disease with organisms of the Mycobacterium avium complex in SIV-infected rhesus macaques. JID 2003, June 1,187(11), 1748-55.

Didier PJ, Snowden K, Alvarez, X, Didier ES. 2003. Microsporidiosis, in Infectious Diseases of the Dog and Cat, CE Greene (ed), 3rd edition, W.B. Saunders, Orlando, FL, 2004, in press.

Sestak K, Merritt CK, Borda J, Saylor E, Schwamberger SR, Cogswell F, Didier ES, Didier PJ, Plauche G, Bohm RP, Aye PP, Alexa P, Ward RL, Lackner AA. Infectious agent and immune response characteristics of chronic enterocolitis in captive rhesus macaques. Infect Immun. 2003 Jul;71(7):4079-86.

Safi H, Gormus BJ, Didier PJ, Blanchard JL, Lakey DL, Martin LN, Murphey-Corb M, Vankayalapati R, Barnes PF. Spectrum of manifestations of Mycobacterium tuberculosis infection in primates infected with SIV.AIDS Res Hum Retroviruses. 2003 Jul;19(7):585-95.43. Didier ES, Stovall ME, Green LC, Bowers L, Fredenburg A, Didier PJ. Diagnosis and epidemiology of human microsporidia infections. [ABSTRACT],Abstract 220. 4th Seminar on Food- and Waterborne Parasitic Zoonoses and the Joint International Tropical Medicine Meeting, Bangkok, Thailand, Dec 2-4.

Didier, E.S., M.E. Stovall, A.D. Martin, X. Alvarez, L.C. Bowers, P.F. Brindley, A. Plauche, P.J. Didier. 2003. Methionine aminopeptidase 2 expression in microsporidia. J. Euk. Microbiol. 50(suppl.):569-571.
45. Ratterree MS, Gutierrez RA, Travassos da Rossa AP, Dille BJ, Beasley DW, Bohm RP, Desai SM, Didier PJ, Bikenmeyer LG, Dawson GJ, Leary TP, Schochetman G, Phillippi-Falkenstein K, Arroyo J, Narrett AD, Tesh RB. Experimental infection of rhesus macaques with West Nile virus: level and duration of viremia and kinetics of the antibody response after infection. J Infect Dis 2004 Feb 15;189(4):669-76.

Lyashchenko K, Greenwald R, Esfandiari J, Houghton R, Pollock J, Andersen P, Gibson, Didier P, McCombs C. Serological responses in experimental monkey tuberculosis. ABSTRACT, 7th Int. Vet. Immunol. Sump. in Quebec City (July 2004), in press.

Gormus BJ, Blanchard JL, Alvarez XH, Didier PJ. Evidence for a rhesus monkey model of asymptomatic tuberculosis. J Med Primatol 2004; 33:134-145.

Green LC, Didier PJ, Bowers LC, Didier ES. Natural and experimental infection of immunocompromised rhesus macaques (Macaca mulatta) with the microsporidian Enterocytozoon bieneusi genotype D. Microbes Infect. 2004 Sep;6(11):996-1002.

Didier, E.S., P.J. Didier, M.E. Stovall, L.C. Bowers, P.J. Brindley. 2004. Preclinical evaluations of therapies for microsporidial infections. First NATO United Workshop on Microsporidia of Invertebrate and Vertebrate Hosts: Emerging Pathogens in the 21st Century, Ceske Budejovice, Czech Republic, July 12-15, 2004.

Didier, E.S., M.E. Stovall, L.C. Green, P.J. Didier, L.C. Bowers, A. Fredenburg, and C.R. Vossbrinck. Immunomagnetic bead capture assay for detection and identification of microsporidia. 104th General Meeting of the American Society for Microbiology [ABSTRACT C-369], p. 209, 2004.

Didier ES, Vossbrinck CR, Stovall ME, Green LC, Bowers LC, Fredenburg A, Didier PJ 2004. Diagnosis and epidemiology of human microsporidia infections. U.S. Environmental Protection Agency (publication number to be deterimined – in press).

Mehra S, Golden NA, Dutta NK, Midkiff CC, Alvarez X, Doyle LA, Asher M, Russell-Lodrigue K, Monjure C, Roy CJ, Blanchard JL, Didier PJ, Veazey RS, Lackner AA, Kaushal D.  2011. Reactivation of latent tuberculosis in rhesus macaques by coinfection with simian immunodeficiency virus. J Med Primatol. Aug; 40(4):233-43.

 

Level of Instruction:

graduate


[View all Tropical Medicine faculty]

 

 
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Department of Tropical Medicine, 1440 Canal Street, Suite 2210, New Orleans, LA 70112, 504-988-3558 tropmed@tulane.edu