Ahmed Aly, PhD
Tulane University School of Public Health and Tropical Medicine
1430 Tulane Avenue, Room 132
J Bennett Johnston Bldg.
New Orleans, LA 70112
My research is focusing on the biology and host-parasite interactions
of the malaria parasite in the mosquito and the mammalian hosts. My
ultimate research goals are to discover novel potent drug targeting and
subunit vaccine candidates and the generation of effective and safe
whole organism vaccines to help eradicate the malaria disease. I aim to
use my expertise in Plasmodium targeting techniques in the generation of attenuated parasites as live vaccines and tailor-made transgenic Plasmodium parasite strains as tools to explore the functions of various Plasmodium proteins and their essential roles in the malaria parasite life cycle. I will use the rodent malaria parasite models and Anopheles mosquitoes to generate and study all life cycle stages of Plasmodium.
Host-Parasite Interaction; Malaria Vaccine Development
- 2006 - 2010 Post Doctoral Fellow, Seattle Biomedical Research Institute.
- 2005 PhD. Heidelberg University, Heidelberg, Germany.
- 2001 M.Sc., University of Ulm, Ulm, Germany.
- 1995 B.Sc., Ain Shams University, Cairo, Egypt.
- 2005 - Award for an outstanding presentation at the XVI
International Molecular Parasitology Meeting, Woods Hole,
- 2008 - Listed as an inventor on US and Australians patents entitled "Live Genetically Attenuated Malaria Vaccines."
- 2012 - Award of Tulane COR fellowship of $10,000.
Aly, AS and K
Matuschewski. (2005) "A malarial cysteine protease is necessary for
Plasmodium sporozoite egress from oocysts." Journal of Experimental
Medicine. 202(2): p. 225-30.
Mikolajczak, SA, AS Aly, and SH Kappe.(2007) "Preerythrocytic malaria vaccine development." Current Opinion in Infectious Diseases. 20(5): p. 461-6.
Aly, AS, SA
Mikolajczak, HS Rivera, N Camargo, V Jacobs-Lorena, M Labaied, I
Coppens, and SH Kappe.(2008) "Targeted deletion of SAP1 abolishes the
expression of infectivity factors necessary for successful malaria
parasite liver infection." Molecular Microbiology. 69(1): p. 152-63.
Mikolajczak, SA, AS Aly,
RF Dumpit, AM Vaughan, and SH Kappe.(2008) "An efficient strategy for
gene targeting and phenotypic assessment in the Plasmodium yoelii rodent
malaria model." Molecular and Biochemical Parasitology. 158(2): p.
Mikolajczak, SA, H Silva-Rivera, X Peng, AS Tarun, N Camargo, V Jacobs-Lorena, TM Daly, LW Bergman, P de la Vega, J Williams, AS Aly,
and SH Kappe.(2008) "Distinct malaria parasite sporozoites reveal
transcriptional changes that cause differential tissue infection
competence in the mosquito vector and mammalian host." Molecular and
Cellular Biology. 28(20): p. 6196-207.
Vaughan, AM, AS Aly,
and SH Kappe.(2008) "Malaria parasite pre-erythrocytic stage infection:
gliding and hiding." Cell Host and Microbe. 4(3): p. 209-18.
Vaughan, AM, MT O'Neill, AS Tarun, N Camargo, TM Phuong, AS Aly,
AF Cowman, and SH Kappe.(2009) "Type II fatty acid synthesis is
essential only for malaria parasite late liver stage development."
Cellular Microbiology. 11(3): p. 506-20.
VanBuskirk, KM, MT O'Neill, P De La Vega, AG Maier, U Krzych, J
Williams, MG Dowler, JB Sacci, Jr., N Kangwanrangsan, T Tsuboi, NM
Kneteman, DG Heppner, Jr., BA Murdock, SA Mikolajczak, AS Aly,
AF Cowman, and SH Kappe.(2009) "Preerythrocytic, live-attenuated
Plasmodium falciparum vaccine candidates by design." Proceedings of the
National Academy of Sciences U S A. 106(31): p. 13004-9.
Aly, AS, AM
Vaughan, and SH Kappe.(2009) "Malaria Parasite Development in the
Mosquito and Infection of the Mammalian Host." Annual Review of
Microbiology. 63: p. 195-221.
Aly, AS, MJ
Downie, C Ben Mamoun , SH Kappe.(2010) "Sterile protection against
lethal malaria by single subpatent immunization with a genetically
attenuated blood stage vaccine." Cellular Microbiology. 12(7): p. 930-8.
MacKellar, DC, MT O'Neill, AS Aly,
AF Cowman, SH Kappe.(2009) "A putative Plasmodium falciparum UIS4
localizes to the parasitophorous vacuole but does not complement lack of
UIS4 in the liver stage of Plasmodium yoelii." Eukaryotic Cell. 9(5):
Aly, AS, SE
Lindner, D Mackellar, X Peng, and SH Kappe. (2011) "SAP1 is a critical
posttranscriptional regulator of infectivity in malaria parasite
sporozoite stages." Molecular Microbiology. 79(4): p. 929-39.
NS Butler, NW Schmidt, AM Vaughan, AS Aly,
SH Kappe, JT Harty (2011) "Superior anti-malarial immunity after
vaccination with late-liver-stage arresting genetically attenuated
parasites." Cell Host and Microbe. 9(6): p.451-62.
McKellar, DC, AM Vaughan, AS Aly,
S DeLeon, SH Kappe (2011) "A systematic analysis of the early
transcribed membrane protein family throughout the life cycle of
Plasmodium yoelii." Cellular Microbiology. 13(11): p. 1755–1767.