Ahmed Aly, PhD
Tulane University School of Public Health and Tropical Medicine
1430 Tulane Avenue, Room 132
J Bennett Johnston Bldg.
New Orleans, LA 70112
Aly Laboratory Website
My research is focusing on the biology and host-parasite interactions
of the malaria parasite in the mosquito and the mammalian hosts. My
ultimate research goals are to discover novel potent drug targeting and
subunit vaccine candidates and the generation of effective and safe
whole organism vaccines to help eradicate the malaria disease. I aim to
use my expertise in Plasmodium targeting techniques in the generation of attenuated parasites as live vaccines and tailor-made transgenic Plasmodium parasite strains as tools to explore the functions of various Plasmodium proteins and their essential roles in the malaria parasite life cycle. I will use the rodent malaria parasite models and Anopheles mosquitoes to generate and study all life cycle stages of Plasmodium.
Host-Parasite Interaction; Malaria Vaccine Development
- 2006 - 2010 Post Doctoral Fellow, Seattle Biomedical Research Institute.
- 2005 PhD. Heidelberg University, Heidelberg, Germany.
- 2001 M.Sc., University of Ulm, Ulm, Germany.
- 1995 B.Sc., Ain Shams University, Cairo, Egypt.
- 2005 - Award for an outstanding presentation at the XVI
International Molecular Parasitology Meeting, Woods Hole,
- 2008 - Listed as an inventor on US and Australians patents entitled "Live Genetically Attenuated Malaria Vaccines."
- 2012 - Award of Tulane COR fellowship of $10,000.
Aly AS, Lindner SE, Mackellar D, Peng X, SH Kappe SH. (2011). SAP1 is a critical
posttranscriptional regulator of infectivity in malaria parasite
sporozoite stages. Molecular Microbiology, 79(4), 929-39.
Butler NS, Schmidt NW, Vaughan AM, Aly AS, Kappe SH, Harty JT. (2011). Superior anti-malarial immunity after
vaccination with late-liver-stage arresting genetically attenuated
parasites. Cell Host and Microbe., 9(6), 451-62.
McKellar DC, Vaughan AM, Aly AS, DeLeon S, Kappe SH. (2011). A systematic analysis of the early
transcribed membrane protein family throughout the life cycle of
Plasmodium yoelii. Cellular Microbiology. 13(11), 1755–1767.
Aly AS, Downie MJ, Mamoun CB, Kappe SH. (2010). Sterile protection against
lethal malaria by single subpatent immunization with a genetically
attenuated blood stage vaccine. Cellular Microbiology, 12(7), 930-8.
Mackellar DC, O'Neill MT, Aly AS, Sacci JB Jr, Cowman AF, Kappe SH. (2010). Plasmodium falciparum PF10_0164 (ETRAMP10.3) is an essential parasitophorous vacuole and exported protein in blood stages. Eukaryot Cell, 9(5), 784-94.
Aly AS, Downie MJ, Mamoun CB, Kappe SH. (2010). Subpatent infection with nucleoside transporter 1-deficient Plasmodium blood stage parasites confers sterile protection against lethal malaria in mice. Cell Microbiol., 12(7), 930-8.
MacKellar DC, O'Neill MT, Aly AS, Cowman AF, Kappe SH. (2009). A putative Plasmodium falciparum UIS4
localizes to the parasitophorous vacuole but does not complement lack of
UIS4 in the liver stage of Plasmodium yoelii. Eukaryotic Cell, 9(5), 784-94.
Vaughan AM, O'Neill MT, Tarun AS, Camargo N, Phuong TM, Aly AS, Cowman AF, Kappe SH. (2009). Type II fatty acid synthesis is
essential only for malaria parasite late liver stage development.
Cellular Microbiology, 11(3), 506-20.
VanBuskirk KM, O'Neill MT, de La Vega P, Maier AG, Krzych U, Williams J, Dowler MG, Sacci JB, Kangwanrangsan N, Tsuboi T, Kneteman NM, Heppner DG, Murdock BA, Mikolajczak SA, Aly AS, Cowman AF, Kappe SH. (2009). Preerythrocytic, live-attenuated
Plasmodium falciparum vaccine candidates by design. PNAS, 106(31),13004-9.
Aly AS, Vaughan AM, Kappe SH. (2009). Malaria Parasite Development in the
Mosquito and Infection of the Mammalian Host. Annual Review of
Microbiology, 63, 195-221.
Vaughan AM, Aly AS, Kappe SH. (2008). Malaria parasite pre-erythrocytic stage infection:
gliding and hiding. Cell Host and Microbe, 4(3), 209-18.
Mikolajczak SA, Silva-Rivera H, Peng X, Tarun AS, Camargo N, Jacobs-Lorena V, Daly TM, Bergman LW, de la Vega P, Williams J, Aly AS, Kappe SH. (2008). Distinct malaria parasite sporozoites reveal
transcriptional changes that cause differential tissue infection
competence in the mosquito vector and mammalian host. Molecular and
Cellular Biology, 28(20), 6196-207.
Mikolajczak SA, Aly AS, Dumpit RF, Vaughan AM, Kappe SH. (2008). An efficient strategy for
gene targeting and phenotypic assessment in the Plasmodium yoelii rodent
malaria model. Molecular and Biochemical Parasitology, 158(2),
Aly AS, Mikolajczak SA, Rivera HS, Camargo N, Jacobs-Lorena V, Labaied M, Coppens I, Kappe SH. (2008). Targeted deletion of SAP1 abolishes the
expression of infectivity factors necessary for successful malaria
parasite liver infection. Molecular Microbiology, 69(1), 152-63.
Mikolajczak SA, Aly AS, Kappe SH. (2007). Preerythrocytic malaria vaccine development. Current Opinion in Infectious Diseases.,20(5), 461-6.
Aly AS and K
Matuschewski. (2005). A malarial cysteine protease is necessary for
Plasmodium sporozoite egress from oocysts. Journal of Experimental
Medicine, 202(2), 225-30.