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 Ahmed Aly    

Ahmed Aly, PhD
Assistant Professor
Tulane University School of Public Health and Tropical Medicine
1430 Tulane Avenue, Room 132
J Bennett Johnston Bldg.
New Orleans, LA 70112
Phone 504.988.2286
Fax 504.988.6686
aaly@tulane.edu

Aly Laboratory Website




Personal Statement:

My research is focusing on the biology and host-parasite interactions of the malaria parasite in the mosquito and the mammalian hosts. My ultimate research goals are to discover novel potent drug targeting and subunit vaccine candidates and the generation of effective and safe whole organism vaccines to help eradicate the malaria disease. I aim to use my expertise in Plasmodium targeting techniques in the generation of attenuated parasites as live vaccines and tailor-made transgenic Plasmodium parasite strains as tools to explore the functions of various Plasmodium proteins and their essential roles in the malaria parasite life cycle. I will use the rodent malaria parasite models and Anopheles mosquitoes to generate and study all life cycle stages of Plasmodium.

 

Research Interests:

Host-Parasite Interaction; Malaria Vaccine Development



Educational Background:

  • 2006 - 2010 Post Doctoral Fellow, Seattle Biomedical Research Institute.
  • 2005 PhD. Heidelberg University, Heidelberg, Germany.
  • 2001 M.Sc., University of Ulm, Ulm, Germany.
  • 1995 B.Sc., Ain Shams University, Cairo, Egypt.


Professional Achievements:

  • 2005 - Award for an outstanding presentation at the XVI International Molecular Parasitology Meeting, Woods Hole,  Massachusetts, USA.
  • 2008 -  Listed as an inventor on US and Australians patents entitled "Live Genetically Attenuated Malaria Vaccines."
  • 2012  - Award of Tulane COR fellowship of $10,000.

 

Selected Publications:

Aly AS, Lindner SE, Mackellar D, Peng X, SH Kappe SH. (2011). SAP1 is a critical posttranscriptional regulator of infectivity in malaria parasite sporozoite stages. Molecular Microbiology, 79(4), 929-39.

Butler NS, Schmidt NW, Vaughan AM, Aly AS, Kappe SH, Harty JT. (2011). Superior anti-malarial immunity after vaccination with late-liver-stage arresting genetically attenuated parasites. Cell Host and Microbe., 9(6), 451-62.

McKellar DC, Vaughan AM, Aly AS, DeLeon S, Kappe SH. (2011). A systematic analysis of the early transcribed membrane protein family throughout the life cycle of Plasmodium yoelii. Cellular Microbiology. 13(11), 1755–1767.

Aly AS, Downie MJ, Mamoun CB, Kappe SH. (2010). Sterile protection against lethal malaria by single subpatent immunization with a genetically attenuated blood stage vaccine. Cellular Microbiology, 12(7), 930-8.

Mackellar DC, O'Neill MT, Aly AS, Sacci JB Jr, Cowman AF, Kappe SH. (2010). Plasmodium falciparum PF10_0164 (ETRAMP10.3) is an essential parasitophorous vacuole and exported protein in blood stages. Eukaryot Cell, 9(5), 784-94.

Aly AS, Downie MJ, Mamoun CB, Kappe SH. (2010). Subpatent infection with nucleoside transporter 1-deficient Plasmodium blood stage parasites confers sterile protection against lethal malaria in mice. Cell Microbiol., 12(7), 930-8.

MacKellar DC, O'Neill MT, Aly AS, Cowman AF, Kappe SH. (2009). A putative Plasmodium falciparum UIS4 localizes to the parasitophorous vacuole but does not complement lack of UIS4 in the liver stage of Plasmodium yoelii. Eukaryotic Cell, 9(5), 784-94.

Vaughan AM, O'Neill MT, Tarun AS, Camargo N, Phuong TM,  Aly AS, Cowman AF, Kappe SH. (2009). Type II fatty acid synthesis is essential only for malaria parasite late liver stage development. Cellular Microbiology, 11(3), 506-20.

VanBuskirk KM, O'Neill MT, de La Vega P, Maier AG, Krzych U, Williams J, Dowler MG, Sacci JB, Kangwanrangsan N, Tsuboi T, Kneteman NM, Heppner DG, Murdock BA, Mikolajczak SA, Aly AS, Cowman AF, Kappe SH. (2009). Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design. PNAS, 106(31),13004-9.

Aly AS, Vaughan AM, Kappe SH. (2009). Malaria Parasite Development in the Mosquito and Infection of the Mammalian Host. Annual Review of Microbiology, 63, 195-221.

Vaughan AM, Aly AS, Kappe SH. (2008). Malaria parasite pre-erythrocytic stage infection: gliding and hiding. Cell Host and Microbe, 4(3), 209-18.

Mikolajczak SA, Silva-Rivera H, Peng X, Tarun AS, Camargo N, Jacobs-Lorena V, Daly TM, Bergman LW, de la Vega P, Williams J, Aly AS, Kappe SH. (2008). Distinct malaria parasite sporozoites reveal transcriptional changes that cause differential tissue infection competence in the mosquito vector and mammalian host. Molecular and Cellular Biology, 28(20), 6196-207.

Mikolajczak SA, Aly AS, Dumpit RF, Vaughan AM, Kappe SH. (2008). An efficient strategy for gene targeting and phenotypic assessment in the Plasmodium yoelii rodent malaria model. Molecular and Biochemical Parasitology, 158(2), 213-6.

Aly AS, Mikolajczak SA, Rivera HS, Camargo N, Jacobs-Lorena V, Labaied M, Coppens I, Kappe SH. (2008). Targeted deletion of SAP1 abolishes the expression of infectivity factors necessary for successful malaria parasite liver infection. Molecular Microbiology, 69(1), 152-63.

Mikolajczak SA, Aly AS, Kappe SH. (2007). Preerythrocytic malaria vaccine development. Current Opinion in Infectious Diseases.,20(5), 461-6.

Aly AS and K Matuschewski. (2005). A malarial cysteine protease is necessary for Plasmodium sporozoite egress from oocysts. Journal of Experimental Medicine, 202(2), 225-30.

 
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Department of Tropical Medicine, 1440 Canal Street, Suite 2210, New Orleans, LA 70112, 504-988-3558 tropmed@tulane.edu