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Juan C. Pizarro, PhD
Assistant Professor
Department of Tropical Medicine
Tulane University School of Public Health and Tropical Medicine
J Bennett Johnston Bldg. Room 133
1430 Tulane Avenue
New Orleans, LA 70112
Phone: (504) 988-2287
Fax: (504) 988-6686
jpizarro@tulane.edu
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Research Interests:
To investigate the interactions between human and parasite proteins to understand the host-parasite relationship between Plasmodium falciparum and its human host.
Educational Background:
- Doctorat en Sciences (PhD), Université de Paris XI, 2001, Paris, France
- DEA (M. Sc.), Université de Paris XI, 1997, Paris, France
- B. Sc., Universidad de Los Andes, 1996, Colombia
Professional Achievements:
- Fondation pour la Recherche Médicale fellowship, 2000 – 2001
- Association pour la Recherche sur le Cancer (ARC) fellowship, 1999 – 2000
Selected Publications:
Qiu, W., Dong A., Pizarro J. C., Botchkarev A., Min J., Wernimont A. K., Hills T., Hui R. and Artz J. D. – 2012 "Crystal structures from the Plasmodium peroxiredoxins: new insights into oligomerization and product binding" BMC Structural Biology 12(1): 2
Pizarro J. C., Boulot G., Bentley G. A., Gómez K. A., Hoebeke J., Hontebeyrie M., Levin M. J. and Smulski C. R. – 2011 "Crystal Structure of the Complex mAb 17.2 and the C-Terminal Region of Trypanosoma cruzi P2β Protein: Implications in Cross-Reactivity" PLoS Neglected Tropical Diseases 5(11): e1375.
Hills T., Srivastava A., Wernimont A., Ayi K., Kain K., Waters A. P., Hui R. and Pizarro J. C. – 2010 "Characterization of a new phosphatase from Plasmodium falciparum associated with schizogony" Molecular and Biochemical Parasitology 179(2): 69-79.
Xu B., Pizarro J. C., Holmes M., McBeth C., Groh V., Spies T. and Strong R. K. – 2010 "Crystal Structure of a γδ T Cell Receptor Specific for the Human MHC Class I Homolog MICA" Proceedings of the National Academy of Sciences 108(6): 2414-2419.
Wernimont A. K., Amani M., Qiu W., Pizarro J. C., Artz J. D., Lin Y.-H., Lew J., Hutchinson A. and Hui R. – 2010 "Structures of parasitic CDPK domains point to a common mechanism of activation" Proteins: Structure, Function, and Bioinformatics 79(3): 803-820
Bakszt R., Wernimont A., Hassani A., Hui R. and Pizarro J. C. – 2010 "The Crystal Structure of Toxoplasma gondii Pyruvate Kinase" PLoS ONE 5(9): e12736.
Bao G., Clifton M., Hoette T. M., Mori K., Deng S.-X., Qiu A., Viltard M., Williams D., Paragas N., Leete T., Kulkarni R., Li X., Lee B., Kalandadze A., Ratner A. J., Pizarro J. C., Schmidt-Ott K. M., Landry D. W., Raymond K. N., Strong R. K. and Barasch J.– 2010 "Iron Traffics in Circulation Bound to a Siderocalin (Ngal)-Catechol Complex" Nature Chemical Biology 6(8): 602-609.
Abergel R. J., Clifton M. C., Pizarro J. C., Warner J. A., Shuh D. K., Strong R. K. and Raymond K. N. – 2008 "The Siderocalin/Enterobactin Interaction: A Link between Mammalian Immunity and Bacterial Iron Transport" Journal of the American Chemical Society 130(34): 11524-11534
Kaiser B., Pizarro J. C., Kerns J. and Strong R. K. – 2008 "Structural basis for NKG2A/CD94 recognition of HLA-E" Proceedings of the National Academy of Sciences 105(18): 6696-6701.
Chesne-Seck M.-L., Pizarro J. C., Vulliez-Le Normand B., Collins C. R., Blackman M. J., Faber B. W., Remarque E. J., Kocken C. H.M., Thomas A. W., Bentley G. A. – 2005 "Structural comparison of apical membrane antigen 1 orthologues and paralogues in apicomplexan parasites" Molecular and Biochemical Parasitology 144: 55-67.
Pizarro J. C., Vulliez-Le Normand B., Chesne-Seck M.-L., Collins C. R., Withers-Martinez C., Hackett F., Blackman M. J., Faber B. W., Remarque E. J., Kocken C. H.M., Thomas A. W., Bentley G. A. – 2005 "Crystal structure of the malaria vaccine candidate Apical Membrane Antigen 1" Science 308: 408-411
Piñeyro M. D.*, Pizarro J. C.*, Lema F., Pritsch O., Cayota A., Bentley G. A. and Robello C. – 2005 "Crystal structure of the tryparedoxin peroxidase from the human parasite Trypanosoma cruzi" Journal of Structural Biology 150: 11-22. * Authors contributing equally to the work
Oppezzo P., Dumas G., Bouvet J. P., Robello C., Cayota A., Pizarro J. C.,. Dighiero G. and Pritsch O. – 2004 "Somatic mutations can lead to a loss of superantigenic and polyreactive binding" European Journal of Immunology 34(5):1423-1432
Pizarro J. C., Chitarra V., Verger D., Holm I., Pêtres S., Dartville S., Nato F., Longacre S. and Bentley G. A. -2003 "Crystal Structure of a Fab Complex Formed with PfMSP1-19, the C-Terminal Fragment of Merozoite Surface Protein 1 from Plasmodium falciparum: A Malaria vaccine candidate" Journal of Molecular Biology 328(5):1091-103
Pizarro J. C., Vulliez-Le Normand B., Riottot M.-M., Budkowska A. and Bentley G. A. – 2001 "Structural and functional characterization of a monoclonal antibody specific for the PreS1 region of Hepatitis B virus" FEBS letters 509: 463-468
Romaña C. A., Pizarro J. C., Rodas E. and Gilbert E. - 1999 "Palm trees as ecological indicators of risk areas for Chagas disease" Transactions of the Royal Society of Tropical Medicine and Hygiene, 93: 594-595
Pizarro J. C. and Romaña C. A. -1998 "Variación estacional de una poblacion silvestre de Rhodnius pallescens Barber, 1932 (Heteroptera: Triatominae) en la costa caribe colombiana" Bulletin de l'IFEA 27(2): 309-325
Level of Instruction:
graduate
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