Epidemiology

Jinying Zhao, MD PhD Associate Professor Department of Epidemiology Tulane University School of Public Health and Tropical Medicine 1440 Canal Street, Suite 2000 New Orleans, LA 70112 Phone: (504) 988-3056 Fax: (504) 988-1568 jzhao5@tulane.edu Curriculum Vitae

Research Interests:

 Statistical genetics, cardiovascular genetic epidemiology, epigenetics, bioinformatics

Educational Background:

• PhD in Statistical Genetics, University of Texas Health Science Center at Houston, Houston, TX
  
• PhD in Molecular Genetics, Chinese Academy of Medical Sciences, Beijing, China
  
• MSc in Pathology, Zhengzhou University School of Medicine, Zhengzhou, China
  
• MD, Zhengzhou University School of Medicine, Zhengzhou, China
  

Professional Achievements:

• Roger R. Williams Award for Genetic Epidemiology, American Heart Association, 2012
• Outstanding Faculty Award in Research or Scholarly Achievement, University of Oklahoma Health Science Center, 2010
• Sandra Daugherty Award for Excellence in Cardiovascular Disease or Hypertension Epidemiology, American Heart Association, finalist, 2009
• The Elizabeth Barrett-Connor Research Award for Young Investigators, American Heart Association, 2006

Selected Publications:

Zhao J, Forsberg CW, Goldberg J, Smith NL, Vaccarino V. MAOA promoter methylation and susceptibility to carotid atherosclerosis: role of familial factors in a monozygotic twin sample.BMC Med Genet. 2012 Nov 2;13:100.

Yang J, Zhu Y, Lee ET, Zhang Y, Cole SA, Haack K, Best LG, Devereux RB, Roman MJ, Howard BV, Zhao J. Joint Associations of 61 Genetic Variants in the Nicotinic Acetylcholine Receptor Genes with Subclinical Atherosclerosis in American Indians: A Gene-Family Analysis. Circ Cardiovasc Genet. 2012 Dec 22.

Zhao J, Goldberg J, Vaccarino V. Leukotriene A4 hydrolase haplotype, diet and atherosclerosis: A twin study. Atherosclerosis. 2012 Oct 31. doi:pii: S0021-9150(12)00734-4. 10.1016/j.atherosclerosis.2012.10.048.

Zhao J, Goldberg J, Bremner JD, Vaccarino V. Global DNA methylation is associated with insulin resistance: a monozygotic twin study. Diabetes 2012; 61(2):542-6

Zhao J, Goldberg J, Vaccarino V.Promoter methylation of the serotonin transporter gene is associated with obesity measures: a monozygotic twin study. International Journal of Obesity  2012 Jan 31. doi: 10.1038/ijo.2012.8. [Epub ahead of print]

Yang J. Cole SA, Haack K, Zhang Y, Howard BV, Best LG, Devereux RB, Henderson JA, Henderson P, Lee ET, Zhao J. A gene-set analysis of 61 genetic variants in the nicotinic acetylcholine receptor genes for insulin resistance and type 2 diabetes in American Indians. Diabetes 2012; 61(7):1888-94

Yang J, Zhao J. Cumulative effect of common genetic variants predicts incident type 2 diabetes: a study of 21,183 subjects from three large prospective cohorts. Epidemiol 2011; 1:108.

PatelRS, Su S, Neeland IJ, Ahuja A, Veledar E, Zhao J, Helgadottir A, Holm H, Gulcher JR, Stefansson K, Waddy S, Vaccarino V, Zafari AM, Quyyumi AA. The chromosome 9p21 risk locus is associated with angiographic severity and progression of coronary artery disease. Eur Heart J. 2010; 31(24):3017-23

Peng G, Luo L, Siu H, Zhu Y, Hu P, Hong S, Zhao J, Zhou X, Reveille JD, Jin L, Amos CI, Xiong M. Gene and pathway-based second-wave analysis of genome-wide association studies. Eur J Hum Genet. 2010; 18: 111–117

Zhao J, Quyyumi AA, Patel R, Zafari AM, Veledar E, Onufrak S, Shallenberger LH, Jones L, Vaccarino V. Sex-specific association of depression and a haplotype in leukotriene A4 hydrolase gene. Psychosom Med. 2009;71(7):691-6

Vaccarino V, Votaw J, Faber T, Veledar E, Murrah NV, Jones LR, Zhao J, Su S, Goldberg J, Raggi JP, Quyyumi AA, Sheps DS, Bremner JD. Major depression and coronary flow reserve detected by positron emission tomography. Arch Intern Med. 2009; 169 (18):1668-76.

Su S, Zhao J, Bremner JD, Miller AH, Tang W, Bouzyk M, Snieder H, Novik O, Afzal N, Goldberg J, Vaccarino V. Serotonin transporter gene, depressive symptoms and interleukin-6. Circ Cardiovas Genet 2009; 2:614-620

Su S. Lampert R, Zhao J, Bremner JD, Miller A, Snieder H, Lee F, Khan D, Goldberg J, Vaccarino V. Pleiotropy of C-reactive protein gene polymorphisms with C-reactive protein levels and heart rate variability in healthy male twins. Am J Cardiol. 2009; 104 (12):1748-54.

Zhao J, Cheema FA, Bremner JD, Goldberg J, Su S, Snieder H, Maisano C, Jones L, Javed F, Murrah N, Le NA and Vaccarino V. Heritability of carotid intima-media thickness: a twin study.  Atherosclerosis 2008;197:814-820

Su S, Snieder H, Miller AH, Ritchie J, Bremner JD, Goldberg J, Dai J, Jones L, Murrah NV, Zhao J, Vaccarino V. Genetic and environmental influences on systemic markers of inflammation in middle-aged male twins. Atherosclerosis. 2008; 200(1):213-20

Zhao J, Cheema FA, Reddy U, Bremner JD, Su S, Goldberg J, Snieder H, and Vaccarino V. Heritability of flow-mediated dilation: a twin study. J Thromb Haemost  2007; 5 (12) : 2386-2392.

Zhao J, Boerwinkle E, Xiong M. An entropy-based genome-wide transmission/disequilibrium test. Hum Genet  2007; 121(3-4): 357-67

Lee EB, Zhao J (Equal Contribution First Author), Kim JY, Xiong MM and Song YW.  Evidence of potential interaction of chemokine genes in systemic sclerosis susceptibility. Arthritis and Rheumatism  2007; 56(7):  2443-2448

Lee EB, Kim JY, Zhao J, Park MH, Song YW.  Haplotype association of IL-8 gene with Behcet's disease.  Tissue Antigens 2007; 69(2): 128-132

Zhao J, Jin L, Xiong MM. Test interaction between two unlinked loci. Am J Hum Genet  2006 ; 79(5) : 831-845

Zhao J, Jin Li, Xiong MM. Nonlinear tests for genome-wide association studies. Genetics 2006 ; 174:1529-1538

Zhao J, Boerwinkle E, Xiong MM. Impact of haplotype frequency estimation error on test statistics in association studies. Am J Hum Genet 2006 ; 78 : 728-729

Zhao J, Boerwinkle E and Xiong MM.  An entropy-based statistic for genome-wide association studies.  Am J Hum Genet 2005; 77: 27-40

Zhao J, Xiong MM, Huang W, et al. An autosomal genomic scan for loci linked to type 2 diabetes in northern Han Chinese population. J Mol Med 2005; 209: 209-215

Xiong MM, Zhao J, Xiong H. Network-based regulatory pathways analysis. Bioinformatics 2004; 20(13):2056-2066

Xiong MM, Zhao J, Boerwinkle E. Haplotype block linkage disequilibrium mapping. Frontiers in Bioscience 2003; 8: 85-93

Xiong MM, Zhao J, Boerwinkle E. Generalized T² test for genome association studies. Am J Hum Genet 2002; 70:1257-1268

Zhao J, Li WJ and Xiong MM. Population-based linkage disequilibrium mapping of QTL: An application to simulated data in an isolated population. Genet Epidemiology 2001; 21(Suppl 1): S655-S659

Xiong MM, Li WJ, Zhao J, Jin L and Boerwinkle E. Feature (gene) selection in gene expression-based tumor classification. Molecular Genetics and Metabolism 2001; 73: 239-247

Xiong MM, Fang XZ, Zhao J.  Biomarker identification by feature wrappers. Genome Research 2001; 11:1878-1887

Level of Instruction:

Graduate

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