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 Nick Makridakis    

Nick Makridakis, PhD
Assistant Professor
Department of Epidemiology
Tulane University School of Public Health and Tropical Medicine
1440 Canal Street, Suite 2000
New Orleans, LA 70112
Phone: (504) 988-6809
Fax: (504) 988-1568
nmakrida@tulane.edu

 



Research Interests:

Molecular Epidemiology of cancer and other multifactorial diseases

 

Educational Background:

  • Postdoctoral Fellowship, University of Southern California
  • PhD, University of Southern California, Los Angeles, CA
  • BS, University of Athens, Athens, Greece

Professional Achievements:

 

  • Certificate for Oustanding Scientific Achievement: Louisiana Cancer Research Consortium, Second Annual Scientific Retreat, 2009
  • ACS Clinical Research Post-Doctoral Fellowship, 1998-00
  • Bodosakis Fellowship Foundation Graduate School Fellowship, 1990-93
  • California Foundation for Biochemical Research Graduate Research Fellowship, 1990-91

Selected Publications:

 

Reichardt, J.K.V., Makridakis, N., Henderson, B.E., Yu, M.C., Pike, M.C. and Ross, R.K. (1995) Genetic Variability of the Human SRD5A2 Gene: Implications for Prostate Cancer Risk. Cancer Res. 55: 3973-3975.

Makridakis, N., Ross, R.K., Pike, M.C., Chang, L., Stanczyk, F.Z., Kolonel, L.N., Shi, C.-Y., Yu,M.C., Henderson, B.E. and Reichardt, J.K.V. (1997) A Prevalent Missense Substitution that Modulates Activity of Prostatic Steroid 5a-Reductase. Cancer Res. 57: 1020-1022.  

Makridakis, N.M., Ross, R.K, Pike, M.C., Crocitto, L.E., Kolonel, L.N., Pearce, C.L., Henderson, B.E. and Reichardt, J.K.V. (1999) Association of Missense Substitution in the SRD5A2 Gene with Prostate Cancer in African-American and Hispanic Men in Los Angeles USA. The Lancet 354: 975-978.

Makridakis, N.M., di Salle, E. and Reichardt, J.K.V. (2000) Biochemical and Pharmacogenetic Dissection of Human Steroid 5a-Reductase Type II. Pharmacogenet. 10: 407-413. 

Makridakis, N.M, and Reichardt, J.K.V. (2001) MAPA: Multiplex Automated Primer Extension Analysis: Simultaneous Genotyping of up to Four Polymorphisms. BioTechniques 31: 1374-1380.  

Pearce, C.L., Makridakis, N.M., Ross, R.K., Pike, M.C., Kolonel, L.N, Henderson, B.E. and Reichardt, J.K.V. (2002) The SRD5A2 V89L Substitution is Not Significantly Associated with Risk of Prostate Cancer in a Multi-Ethnic Population. Cancer Epidemiol Biomarkers Prev, 11: 417-418.  

Makridakis, N.M., and Reichardt, J.K.V. (2003) Molecular Epidemiologic Analysis of Androgen-Metabolic Genes and Prostate Cancer. In: Hormones, Genes and Cancer (Ross, R.K., Ponder, B., and Henderson, B.E., Editors), Oxford University Press, New York, NY.  

Makridakis NM, and Reichardt, JKV. (2004) Molecular Epidemiology of Androgen Metabolic Loci in Prostate Cancer Predisposition and Progression. J. of Urol, 171: S25-S29.

Makridakis NM, Akalu A, and Reichardt JKV. (2004) Identification and Characterization of Somatic Steroid 5a-Reductase (SRD5A2) Mutations in Human Prostate Cancer Tissue Oncogene, 23: 7399-7405.  

Makridakis NM and Reichardt J KV. (2005) Pharmacogenetic Analysis of Human Steroid 5a Reductase Type II: Comparison of Finasteride and Dutasteride, J Mol Endocrinol 34: 617-623.  

Makridakis NM, Buchanan G, Tilley W, and Reichardt J KV. (2005) Androgen Metabolic Genes in Prostate Cancer Predisposition and Progression, Front Biosci, 10: 2892-2903.  

Pearce CL, Van Den Berg DJ, Makridakis N, Reichardt JKV, Ross RK, Pike MC, Kolonel LN, and Henderson BE. (2008). No Association between the SRD5a2 gene A49T missense variant and prostate cancer risk:  lessons learned Hum Mol Genet, 17: 2456-61. 

Makridakis NM, Ferraz L, and Reichardt J KV. (2009). Genomic Analysis of Cancer Tissue Reveals that Somatic Mutations Commonly Occur in a Specific Motif, Hum Mutat 30: 39-48. PMCID: PMC2734471.  

Makridakis NM, Phipps T, Srivastav S, and Reichardt JKV. (2009). PCR-free method detects high frequency of genomic instability in prostate cancer. Nucleic Acids Res.37: 7441-7446. PMCID: PMC2794161  

An C, and Makridakis NM. Systematic Biochemical Analysis of Somatic Missense Mutations of DNA Polymerase b Found In Prostate Cancer Reveal Alteration of Enzymatic Function, Hum Mutat, In Press.  

 

Personal Statement:

I am currently interested in identifying genetic DNA elements in the genes that may affect cancer risk or progression, and characterize their contributions individually, in conjuction and in combination with specific environmental factors (e.g. smoking, diet). Analyzing the biochemical effect of EPHX missense variants identified in colorectal cancer patients. Also, measuring the rate of genomic variation and the degree of genomic heterogeneity in cancer tissue, compared to normal adjacent tissue.

 

Level of Instruction:

graduate

 

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Department of Epidemiology, 1440 Canal Street, Suite 2000, New Orleans, LA 70112, 504-988-6809 tcarter1@tulane.edu