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 Prescott Deininger    

Prescott Deininger, PhD
Professor and Regents Distinguished Chair
Director, Tulane Cancer Center
Department of Epidemiology
Tulane University School of Public Health and Tropical Medicine
1440 Canal Street, Suite 475
New Orleans, LA 70112
Phone: (504) 988-6385
Fax: (504) 988-5516
pdeinin@tulane.edu

 



Research Interests:

Molecular and cancer epidemiology

 

Professional Achievements:

  • Executive editor for Analytical Biochemistry, 1990-present
  • Fellow of the American Association for the Advancement of Sciences, 2008 - present          
  • Member of NIEHS, National Toxicology Program Board of  Scientific Counselors 2005-2007
  • Member of the DOD Breast Cancer Study Section, 1996-07, Chair, 2003-2008
  • Member of NIH Mol. Biology Study Section, 1991-1995, Reviewer Reserve, 1996-1999
  • Member of NIH Site visit for the Eppley Cancer Center, 2004, U. Minn Cancer Center, 2007            
  • Ad hoc Human Genome Study Section and Mol. Biol. Study Section, 1989,1990,2003 
  • American Cancer Society Scholar in Dr. Charles Stiles lab. 1988-89
  • Member of Jackson State University NIH RCMI grant external advisory board 2004-present            
  • Member of the Xavier University NIH RCMI grant external advisory board 2009-present

Educational Background:

  • Postdoc, molecular genetics, MRC Lab. of Mol. Biol., Cambridge, U.K., 1981
  • Postdoc, molecular genetics, Univ. of California, San Diego, CA, 1980
  • PhD, biophysical chemistry, Univ. of California, Davis, CA, 1978
  • AB, chemistry, Univ. of California, Santa Cruz, CA, 1973

Selected Publications:

Belancio VP, Roy-Engel, AM and Deininger P (2010) All y'all need to know 'bout retroelements in cancer.  Semin Cancer Biol 20: 200-210. PMID: 20600922 Chaconas G, Craig N, Curcio MJ, Deininger P, Feschotte C, Levin H, Rice PA, Voytas DF. (2010) Meeting report for mobile DNA 2010. Mobile DNA 1, 20-22. 

Belancio VP, Roy-Engel, A. M., Pochampally, R. R., Deininger, P.: Somatic expression of LINE-1 elements in human tissues. NucAcids Res 2010, 38: 3909-3922.  PMID: 20215437

Lee W, Lee YI, Lee J, Davis LM, Deininger P, Soper SA. (2010) Cross-talk-free dual-color fluorescence cross-correlation spectroscopy for the study of enzyme activity. Anal Chem. 15;82(4):1401-10.  PMID: 20073480 Wallace NA, Belancio VP, Faber Z, Deininger P (2010) Feedback inhibition of L1 and Alu retrotransposition through altered double strand break repair kinetics.  Mobile DNA 1, 22-32.

Zhang K, Fan W, Deininger P, Edwards A, Xu Z, Zhu D: Breaking the computational barrier: a divide-conquer and aggregate based approach for Alu insertion site characterisation. Int J Comput Biol Drug Des 2009, 2:302-322.  PMID: 20090173

M. Comeaux, A Roy-Engel, DJ Hedges and P. Deininger (2009) Diverse Cis Factors Controlling Alu Retrotransposition:  What Causes Alu Elements to Die? Genome Research 19: 545-255. PMID: 19273617

Belancio VP, Deininger PL, Roy-Engel AM (2009) Line dancing in the human genome: transposable elements and disease. Genome Med. 1(10):97. PMID: 19863772

 

Personal Statement:

Dr. Deininger serves as the Director of the Tulane Cancer Center and the co-Director of the Louisiana Cancer Research Consortium.  His doctorate was obtained in chemistry and he has gradually evolved his research more to genetics.  However, he has extensive past experience with biochemistry and protein purification, particularly from the early days of molecular genetics when investigators made their own enzymes.  He has been working on human mobile elements since 1975 and has been NIH R01 funded to study Alu elements continually since 1981.  In addition to studies on the biology and evolution of mobile elements, he has contributed several major technical developments to the field of functional genomics.  These include the development of random shearing for shotgun libraries as a postdoc with Fred Sanger, as well as the first development and patenting of the design of dominant negative mutants for laboratory studies of gene function.  His current work focuses heavily on the role of mobile elements creating human genetic instability, particularly somatic instability that may contribute to cancer or aging. 

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Department of Epidemiology, 1440 Canal Street, Suite 2000, New Orleans, LA 70112, 504-988-6809 tcarter1@tulane.edu