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Charles Miller

   

Charles Miller, PhD
Professor
Department of Global Environmental Health Sciences
Tulane University School of Public Health and Tropical Medicine
1440 Canal Street, Suite 2100
New Orleans, LA 70112
Phone: (504) 988-9061
Fax: (504) 988-1726
rellim@tulane.edu

 



Research Interests:

Toxicity mediated through nuclear receptor signaling pathways; chaperone proteins and environmental stresses induced by xenobiotic compounds; mutagenesis; carcinogenesis; DNA damage and repair


Professional Achievements:

  • Society of Toxicology's Committee on Diversity Initiatives (2005-8)
  • Delta Omega, Public Health Honor Society, 1999
  • Shell Oil graduate fellowship recipient, 1988-90 

Educational Background:

 

  • Post-doctoral, Roswell Park Cancer Inst. Buffalo, New York
  • PhD New York University, New York City, New York
  • BS, University Alabama in Birmingham, Alabama

Selected Publications: 

 

J. Adachi, Y. Mori, S. Matsui, H. Takigami, J. Fujino, H. Kitagawa, C.A. Miller III, T. Kato, K. Saeki, and T. Matsuda. Indirubin and indigo are potent aryl hydrocarbon receptor ligands present in human urine. J Biol. Chem., 276: 31475-8, 2001.

M. Cox and C.A. Miller III. The p23 co-chaperone facilitates human dioxin receptor signaling in a yeast model system. Tox. Lett., 129: 13-21, 2002.

C.A. Miller III. Two tetratricopeptide repeat-containing proteins facilitate human aryl hydrocarbon receptor signaling in yeast, Cellular Signalling, 14:615-23, 2002.

M.B. Cox and C.A. Miller III. Pharmacological and genetic analysis of Hsp90 isoprotein-aryl hydrocarbon  receptor complexes. Molecular Pharmacology, 64:1549-56, 2003.

M.B. Cox and C.A. Miller III. Cooperation of Hsp90 and p23 in aryl hydrocarbon receptor signaling, Cell Stress and Chaperones, 9:4-20, 2004.

I. Grad, T. McKee, P. Ruiz, W. Wurst, T. Floss, C.A. Miller III, D. Picard., The Hsp90 co-chaperone p23 is essential for perinatal survival. Mol Cell Biol. 26:8976-83, 2006.

A. Alnafisi, J. Hughes, G. Wang, and C.A. Miller III, Evaluating polycyclic aromatic hydrocarbons using a yeast bioassay. Env. Toxicol. Chem. 26: 1333-9, 2007.

J. Fox, M. Burow, J. McLachlan, and  C.A. Miller III. Detecting ligands and dissecting nuclear receptor signaling pathways using recombinant strains of the yeast Saccharomyces cerevisiae. Nature Protocols, 3:637-45, 2008.

C. Flaveny, G. Perdew, and C.A. Miller III. The aryl hydrocarbon receptor does not require the p23 co-chaperone for ligand binding and target gene expression in vivo. Toxicology Letters, 189:57-62, 2009.

T. Lai, D. Pociask, M. Ferris, H. Nguyen, C.A. Miller III, A. Brody, and D. E. Sullivan. Small interfering RNAs (siRNAs) targeting TGF-β1 mRNA suppress asbestos-induced expression of TGF-β1 and CTGF in fibroblasts. J. Environ. Pathol. Toxicol. Oncol. 28:109-19, 2009.

C.A. Miller III, X. Tan, M. Wilson, S. Bhattacharyya, PhD; S. Ludwig. Single plasmids expressing human steroid hormone receptors and a reporter gene for use in yeast signaling assays, Plasmid, 63: 73-8, 2010.

 

Personal Statement:

Charles Miller received his bachelor of science degree in biology from the University of Alabama in Birmingham. He worked there as a research associate in the pharmacology and biochemistry departments, as well as at the cancer center. He has studied anti-malarial drug toxicity with Roy Mundy, chemical carcinogenesis with Awni Sarrif, colon cancer biology with Michael Brattain, and the immunology of natural killer cells with Toru Abo and Charles Balch.

He joined Max Costa's laboratory and studied carcinogenic mechanisms of nickel and chromium compounds and earned a doctor of philosophy degree in environmental oncology from the Sackler School of Basic Medical Sciences of New York University. During this time, he was the recipient of a fellowship from Shell Oil Company. His post-doctoral research was conducted in David Kowalski's laboratory at the Roswell Park Cancer Institute. There he described several new DNA replication origins in yeast.

He currently investigates how dioxins, PCBs, PAHs, and other toxic chemicals act through receptor signaling networks, and how Hsp90 and its co-chaperone proteins modulate toxic responses. 


Level of Instruction:

graduate, undergraduate


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GEHS, 1440 Canal Street, Suite 2100, New Orleans, LA 70112, 504-988-5374 gehsinfo@tulane.edu