Michael L. McCaskill, PhD, MPH
Department of Global Environmental Health Sciences
Tulane University School of Public Health and Tropical Medicine
1440 Canal Street, Suite 2100
New Orleans, LA 70112
Phone: (504) 988-0246
Fax: (504) 988-1726
environmental toxicology; xenobiotic-induced metabolic dysregulation of macro-nutrients, health disparities, nutrition and behavior based public health intervention
- Postdoctoral Fellowship University of Nebraska Medical Center Pulmonary, Critical Care, Sleep and Allergy, Omaha NE
- PhD, Pharmacy & Pharmaceutical Sciences ( Toxicology) Florida A&M, Tallahassee, FL
- MPH, (Industrial Hygiene) University of South Carolina, Columbia, SC
- BS, (Environmental Science) University of Florida, Gainesville, FL
- Nebraska Cancer and Smoking Disease Research Program: DADS Inhibits Cigarette Smoke Potentiated DNA Damage Role: 06/12-06/13
- NIH-NIAAA (3 R01 AA017993-02S1) Airway Injury Caused by MAA Adducts, 09/09-06/12
- American Thoracic Society Minority Annual Meeting Presentation Travel Award, 2011
- Florida Education Fund McKnight Doctoral Fellowship, 8/02-08/08
- Golden Key International Honor Society, 2006
- University of South Carolina College of Public Health Graduate Student Award 08/00-05/02
McCaskill ML, Romberger DJ, Devasure JM, Boten J, Sisson JH, Bailey K, Poole JA, Wyatt TA. Alcohol Exposure Alters Mouse Lung Inflammation in Response to Inhaled Dust Nutrients 2012 4(7): 695-710
McCaskill ML, Kharbanda KK, Tuma DJ, Reynolds JD, DeVasure JM, Sisson JH, Wyatt TA. Hybrid malondialdehyde and acetaldehyde protein adducts form in the lungs of mice exposed to alcohol and cigarette smoke. Alcohol Clin Exp Res 2011. 35:1106-1113.
Wyatt TA, Kharbanda KK, McCaskill ML, Tuma DJ, Yanov D, DeVasure J, Sisson JH. Malondialdehyde-acetaldehyde-adducted protein inhalation causes lung injury. Alcohol. 2012
McCaskill ML, Aboyade-Cole, A, Thomas, RD. Diallyl Sulfide Modulates Phase I Gene Expression and Phase II Metabolizing Protein Activity in Diethylstilbestrol-Treated MCF-10A cells. FEF Journal of Interdisciplinary Research (In Press).
McCaskill M.L. “Millview Neighborhood Health Consultation” Port St. Joe, Fl. EPA Facility FLN000407304, Florida Department of Health: prepared for Center for Disease Control, Agency for Toxic Substance Disease Registry, Division of Health Assessment and Consultation. March 2010.
Aboyade-Cole, A., Reed, S., Oriaku, E., McCaskill, M., Thomas, R. “Diallyl Sulfide Inhibits Phip- induced cell death via the inhibition of DNA strand breaks in normal human breast epithelial cells.” Oncology Report. 2008. 20(2):319-323.
My research interests lie at the convergence of environmental pressures, human behavior, and innate responses. An imbalance in any of these three inputs can lead to negative health outcomes at the cellular and genetic level. I am interested in elucidating how compounds exact their deleterious responses, and how those responses can be attenuated. Utilizing in-vitro, in-vivo, and ex-vivo models, I investigate xenobiotic-induced metabolic disturbances, such as ethanol-mediated vitamin D deficiency and DNA damage. My broad scientific interests are xenobiotic-induced metabolic dysregulation, DNA damage, health disparities, and diet and behavior based public health intervention. My areas of expertise are vitamin D metabolism, pulmonary antimicrobial peptides, and malondialdehyde-mediated DNA damage of the pulmonary epithelium.
Level of Instruction:
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