TRMD 6010 - Biological Basis of Disease, 3 credits *
This course provide a foundation of knowledge about the human body in health and disease. It gives an overview of important concepts of the biological mechanisms of disease at the cellular, individual, and societal levels. At the cellular level, the course summarizes DNA and cellular function, genomics, immunology, and vaccination. At the individual and societal levels, the course addresses the most important infectious and non-infectious cause of death worldwide, providing background on their pathophysiology, clinical aspects, patterns of disease occurrence, risk factors, and method of prevention.
Course Learning Objectives
Molecular and Cellular Level
1. Describe the central dogma of biology, including definitions of DNA,
RNA, protein, macromolecule function and classify organ systems.
2. Outline genome structure and organization and discuss cell
cycle control and cancer.
3. Discuss major metabolic pathways, signaling and homeostasis.
4. Discuss inheritance and evolution, and explain and quantify
Physiological and Organ System Level
1. Describe major physiological and organ systems, including immune
and endocrine systems.
2. Identify and describe the basic/major diseases of the organ systems.
3. Describe the role of diet and the aging process as they relate to health
and disease states.
4. Discuss the effects of environmental factors on metabolism
and organ systems.
5. Discuss the effects of behavior on metabolism an organ systems.
6. Describe the effects of infectious diseases on metabolism
and organ systems.
1. Describe the most prevalent global diseases (e.g. cardiovascular)
in terms of:
c. risk factors
d. clinical aspects
e. major issues in prevention and control
Discuss population dynamics (reproduction, fecundity, selection, allele frequencies, fitness, and evolution).
* Individuals having a background in this area or are MD, RN may be able to waive this class and should contact Dr. James email@example.com