GEHS 6600 - Principles of Toxicology, 3 credits
Prerequisites: Some knowledge of biology and chemistry is desirable to the principles of mammalian toxicology. Exposure, dose-response, kinetics and distribution of toxicants, metabolism of toxic agents, factors that affect toxicity, introductory chemical carcinogenesis are discussed.
Course Learning Objectives
The student will be able to:
1. Explain the impact of the conditions of exposure – routes, duration and frequency
– on the toxic effects of compounds.
2. Explain and interpret the relationship between dose and the toxic response.
3. Describe the processes of absorption, distribution, storage and excretion and apply
the principles of toxicant transport across membranes to the uptake, action and
excretion of chemical agents.
4. Describe and characterize the types of reactions in Phase I and Phase II metabolic
pathways and give prototypical examples of each.
5. Compare and contrast 0 order and 1st order toxicokinetics and illustrate the impact
of each on the toxicity of prototypical chemical agents.
6. For each target organ discuss (liver, kidney, lung, nervous system and blood),
explain and characterize the mechanisms of injury and give examples of toxicants
that cause the injury.
7. Identify the acute and chronic effects of hydrocarbons, halogenated hydrocarbons,
pesticides, and heavy metals, characterize their mechanisms of toxicity, and describe
measures to preventive or decrease toxic effects.
8. Apply toxicological principles to mechanism of action of prototypical agents and
illustrate their use as a basis for environmental public health preventive actions.