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Specialized Center of Interdisciplinary Research (SCOR)

 

Genomic Convergence for Female Osteoporosis Risk Genes


 

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Posters and oral presentations

     2007

     2008

     2009

     2010

     2011

Training and mentoring

Inter-disciplinary collaborations

Workshops, seminars, and presentations 


Posters and presentations

 

2007 Posters and Oral Presentations

1.  F. Deng, Y. Liu, C. Jiang, L. Li, S. Wu, Y. Chen, H. Jiang, F. Yang, P. Xiao, S. Xiao, L. Tan, X. Sun, J. Xiong, X. Zhu, M. Liu, S. Lei, X. Chen, J. Xie, G. Xiao, S. Liang, H. Deng. In VivoProteomic Analysis of Circulating Monocytes in Chinese Pre-menopausal Females with Extremely Discordant Bone Mineral Density. (The 29th American Society for Bone and Mineral Research (ASBMR) Annual Meeting, September 2007, #W244)

2.  P. Xiao, Y. Chen, H. Jiang, T. Yang, F. Pan, Z. Tang, Y. Liu, R. Recker, H. Deng. In Vivo Genome-wide Expression Study of Human Blood B Cells Suggests a Novel ESR1 and MAPK3 Network for Postmenopausal Osteoporosis. (The 29th ASBMR Annual Meeting, September 2007, #W263)

3.  Y. Liu, P. Xiao, Y. Guo, S. Lei, F. Deng, X. Chen, L. Li, S. Wu, Y. Chen, H. Jiang, L. Tian, J. Xie, X. Zhu, S. Liang, H. Deng. How is mRNA expression predictive for protein expression? - a correlation study on human circulating monocytes.. (The American Society of Human Genetics (ASHG) Annual Meeting, October 2007)

4.  H. Deng, H. Shen, D. Xiong, R. Recker, C. Papasian, Y. Liu. Association analysis RANKL/RANK/OPG genes with cross-sectional geometry at the femoral neck in Caucasian families. (The ASHG Annual Meeting, October 2007)

5.  L. Zhang, J. Liu, H. Deng. Mutual Information Theory Based Multilocus LD Measure and Its Application to Haplotype Block Partitioning. (The ASHG Annual Meeting, October 2007)

6.  J. Liu, Y. Liu, X. Liu, H. Deng. Bayesian Mapping of Quantitative Trait Loci for Multiple Complex Traits Using Variance Components. (The ASHG Annual Meeting, October 2007)

7.  L. Zhao, X. Liu, L. Wang, J. Liu, Y. Pei, H. Yan, D. Xiong, F. Yang, H. Deng. Genome-wide association study identified a locus on 3p21 for cross-sectional geometry at the femoral neck. (The ASHG Annual Meeting, October 2007)

8.  Y. Liu, X. Liu, L. Wang, J. Liu, L. Zhao, H. Yan, D. Xiong, J. Li, R. Recker, C. Papasian, H. Deng. Genome-wide association study identifies new susceptibility genes for obesity. (The ASHG Annual Meeting, October 2007)

9.  F. Deng, Y. Liu, C. Jiang, L. Li, S. Wu, Y. Chen, H. Jiang, F. Yang, P. Xiao, S. Xiao, L. Tan, X. Sun, J. Xiong, M. Liu, S. Lei, X. Chen, J. Xie, G. Xiao, S. Liang, H. Deng. A Proteomic Analysis of In vivo Circulating Monocytes in Chinese Pre-menopausal Females with Discordant Bone Mineral Density. (The ASHG Annual Meeting, October 2007)

10.  J. Zhang, H. Deng. Gene Selection for Classification of Microarray Data Based on the Bayes Error. (The ASHG Annual Meeting, October 2007)


 2008 Posters and Oral Presentations

1.  D. Xiong, L. Zhao, R. Recker, J. Zmuda, H. Deng. Genome-wide Association Study (GWAS) and Subsequent Replication Studies Identified ADAMTS18 and TGFBR3 as Novel Osteoporosis RiskGenes. (The 30th ASBMR Annual Meeting, September 2008, #1093, concurrent oral, Invited based on competitive basis)

2.  L. Zhao, X. Liu, Y. Liu, L. Wang, Y. Liu, H. Yan, J. Liu, D. Xiong, F. Pan, Z. Tang, T. Yang, X. Chen, Y. Guo, S. Lei, R.  Recker, H. Deng. Genome-wide Association Study Identified RTP3 as a Novel Gene for Bone Strength. (The 30th ASBMR Annual Meeting, September 2008, #SU331)

3.  Y. Guo, J. Wang, T. Yang, F. Pan, F. Zhang, Z. Zhang, X. Liu, Q. Zhou, B. Drees, J. Hamilton, C. Papasian, R. Recker, H. Deng. Genome-wide Association Study Identified Novel Susceptibility Loci for Osteoporosis. (The 30th ASBMR Annual Meeting, September 2008, #SA267)

4.  T. Yang, S. Lei, Y. Guo, F. Pan, Q. Zhou, Z. Zhang, S. Dong, X. Xu, X. Liu, H. Yan, B. Drees, J. Hamilton, C. Papasian, R. Recker, H. Deng. Genome-Wide Copy Number Variation Study Identified a Novel Susceptibility Gene UGT2B17for Osteoporosis. (The 30th ASBMR Annual Meeting, September 2008, #M404)

5.  P. Xiao, X. Chen, F. Pan, Y. Chen, H. Jiang, B. Sha, R. Recker, H. Deng. In vivo Differential Expression Profiling Study on Human Circulating B Cells Suggested a Novel EGFR and CALM3 Network Underlying Smoking and BMD. (The 30th ASBMR Annual Meeting, September 2008, #SU154)

6.  P. Xiao, X. Chen, F. Pan, Y. Chen, H. Jiang, B. Sha, R. Recker, H. Deng. In vivoDifferential Expression Profiling Study on Human Circulating Monocytes Suggested a Novel CRAT and CPT2 Network underlying Smoking and BMD. (The 30th ASBMR Annual Meeting, September 2008, #SU155)

7.  Z. Zhang, S. Lei, F. Deng, F. Zhang, Y. Liu, R. Recker, H. Deng. Bivariate genome-wide linkage scan for Traits BMD & AAM: Effect of Menopause on Linkage Signals. (The ASHG Annual Meeting, November 2008)

8.  S. Lei, L. Tan, X. Liu, L. Wang, H. Yan, Y. Guo, Y. Liu, D. Xiong, J. Li, T. Yang, X. Chen, Y. Guo, F. Deng, Y. Zhang, T. Jin, X. Zhu, S. Levy, C. Papasian, J. Hamilton, R. Recker, and H. Deng. Genome-wide association study identifies FLNB and SBF2 as two novel genes underlying stature variation. (The ASHG Annual Meeting, November 2008)

9.  X. Chen, L. Sun, R. Recker, H. Deng, P. Xiao. Expression profiling study in human B cells identified novel miR-181b, miR-7 and miR-627 MicroRNAs underlying osteoporosis. (The ASHG Annual Meeting, November 2008)

10.  L. Sun, X. Chen, R. Recker, H. Deng, P. Xiao. Expression profiling study on human monocytes identified novel MicroRNAs:miR-126, miR-151 and miR-152 for osteoporosis. (The ASHG Annual Meeting, November 2008)

11.  L. Zhao, T. Jin, Y. Pei, X. Liu, B. Sha, Y. Liu, Y. Liu, R. Recker, H. Deng. Genome-wide scan identified a copy number variation in VPS13B associated with bone strength. (The ASHG Annual Meeting, November 2008)

12.  J. Li, T. Jin, Y. Liu, C. Papasian, H. Deng. Whole-Genome Genetic Difference in DNA Variation between Caucasians and Asians. (The ASHG Annual Meeting, November 2008)

13.  Y. Liu, H. Deng. Pathway-based genome-wide association analyses identified VIP (vasoactive intestinal peptide) as a novel pathway for obesity. (The Obesity Society 2008 Annual Scientific Meeting, October 2008, concurrent oral, Invited based on competitive basis)


2009 Posters and Oral Presentations

1.  H. Deng. Dept. of Biostatistics, School of Public Health, Tulane University, New Orleans, Feb. 26, 2009, "Genetic/Genomic Studies of Complex diseases". (Invited oral presentation)

2.  H. Deng. Dept. of Orthopedic Surgery and Human Genetics/Genomics Center, School of Medicine, University of Maryland, Baltimore, March. 27, 2009, "Genetic/Genomic Studies of Complex diseases". (Invited oral presentation)

3.  H. Deng. Department of Genetics/Genomics, Mount Sina School of Medicine, New York, July 13, 2009,  "Genetic/Genomic Studies of Complex diseases". (Invited oral presentation)

4.  P. Xiao. 2009 ASBMR meeting, Denver (Sept. 12-16), USA. MicroRNA Profiling Study in Human Circulating Monocytes Identified the Significance of miR-151 in the Etiology of Osteoporosis. (Invited oral presentation based on competitive basis).

5.  Y. Guo. 2009 ASBMR meeting (Sept. 12-16), Denver, USA. PTH and IL21R May Underlie Variation of Femoral Neck Bone Mineral Density as Suggested by a Genome-wide Association Study (Invited oral presentation based on competitive basis).

6.  F. Bu. 2009 ASBMR meeting (Sept. 12-16), Denver, USA. Powerful Bivariate Genome-wide Association Analyses and Follow-up Replication Studies Identified Several Pleiotropic Genes for both Obesity and Femoral Neck Geometry. (Invited oral presentation based on competitive basis).

7.  H. Deng. Department of Pediatrics, Kosair Children's Hospital Research Institute, School of Medicine, University of Louisville, Louisville, KY, July 17, 2009, , "Genetic/Genomic Studies of Complex diseases". (Invited oral presentation)

8.  T. Yang, L. Zhang, Y. Guo, Q. Tian, H. Deng. HMGA2 Is Confirmed to be Associated with Human Adult Height and Bone Mineral Density in Caucasian Population. (The 31st ASBMR Annual Meeting, September 2009, #SU0150)

9.  S. Dong, X. Liu, Y. Chen, Y. Guo, H. Deng. Association analyses of RANKL/RANK/OPG gene polymorphisms with femoral neck Compression Strength Index variation in Caucasians. (The 31st ASBMR Annual Meeting, September 2009, #SA0320)

10.  F. Deng, L. Zhao, H. Deng. Genome-wide Copy Number Variation Association Study Suggested VPS13B Gene for Osteoporosis in Caucasian. (The 31st ASBMR Annual Meeting, September 2009, #SA0162)

11.  G. Gao, X. Chen, H. Deng, R. Recker, P. Xiao. Human MicroRNA miR-181b in B Cells Was Related with the Etiology of Osteoporosis. (The 31st ASBMR Annual Meeting, September 2009, #MO0320)

12.  X. Xu, D. Xiong, X. Liu, Y. Guo, Y. Chen, R. Recker, H. Deng. Polymorphisms of Vitamin D–Binding Protein Gene Are Associated with Compression Strength Index Variation in Caucasians. (The 31st ASBMR Annual Meeting, September 2009, #MO0154)

13.  J. Li, J. Zhang, H. Deng. Gene Set Analysis based on Gene Interactions for Microarray Expression Data. (The ASHG Annual Meeting, October 2009)

14.  Y. Pei, J. Li, L. Zhang, H. Deng. Analyses and Comparison of Imputation-based Association Methods. (The ASHG Annual Meeting, October 2009)

15.  H. Deng, J. Li, T. Yang, L. Wang, H. Yan, Y. Zhang, Y. Guo, F. Pan, Z. Zhang, Y. Peng, Q. Zhou, L. He, X. Zhu, H. Deng. Whole genome distribution and ethnic differentiation of copy number variation in Caucasian and Asian populations. (The ASHG Annual Meeting, October 2009)


2010 Posters and Oral Presentations

1.  H. Deng. Department of Orthopedic Surgery, University Tennessee Health Science Center, Memphis, Tennessee, "Musculoskeletal Research involving Orthopedic Surgeons". January 26, 2010. (Invited oral presentation)

2.  H. Deng. University Tennessee Health Science Center, Memphis,  "Genetic/Genomics Studies of Musculoskeletal Diseases". January 27, 2010. (Invited oral presentation)

3.  H. Deng. University Tennessee Health Science Center, Memphis, Tennessee "Building an Inter-multi-disciplinary Institute for Musculoskeletal Research". March 11, 2010. (Invited oral presentation)

4.  H. Deng. Department of Genomics&Proteomics, State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine. "Genetic/Genomics Studies of Complex Diseases". Sept. 21, 2010. (Invited oral presentation)

5.  H. Liu. 2010 Contribution of PTH-mediator CREB to Postnatal Bone Mass in Human and Mouse Through Regulation of Osteoblast Function. Oct. 15-19. ASBMR 2010 Annual Meeting, Toronto, Ontario, Canada. (ASBMR Young Investigator Award, invited oral presentation based on competitive basis)

6.  H. Deng, Invited Speaker, International Conference of Bone Research 2010, Shenzhen, Oct 28-31, 2010, Title: Genetics of Osteoporosis: How / What To Do? (Invited oral presentation)

7.  J. Li. Beyond GWAS: genome-wide re-sequencing for musculoskeletal trait genes. Complete Genomics Incorporation (CGI) 1st User Conference. Oct 12, 2010 (Invited oral presentation)

8.  M. Zhao. transcription regulation of BMP2 expression and bone formation. School of Dentistry of Universty of Missouri at kansas city (UMKC). November 17, 2010 (Invited oral presentation)

9.  Y. Liu. Genetics of obesity and osteoporosis. Children's Mercy Hospital October 8, 2010 (Invited oral presentation)

10.  X. Li, J. Li, S. Lei, X. Chen, H. Shen, Y. Liu, Y. Liu, Q. Tian, H. Deng. Genome-wide bivariate association study suggested the DDX6 gene affecting both obesity and osteoporosis. (The 5th International Conference on Osteoporosis and Bone Research, October 2010, Invited oral presentation based on competitive basis)

11.  R. Pan, Y. Liu, H. Deng, V. Dvornyk. Association analyses suggest the effects of RANK/RANKL genes on age at menarche in Chinese. (The 5th International Conference on Osteoporosis and Bone Research, October 2010, Invited oral presentation based on competitive basis)

12.  H. Liu, R. Zhang, S. Ko, C. Papasian, H. Deng, M. Zhao. Microtubule dynamics affect bone mass by regulating both osteoblast and osteoclast function — Stathmin deficiency produces an osteopenic phenotype in mice. (The 5th International Conference on Osteoporosis and Bone Research, October 2010, Invited oral presentation based on competitive basis)

13.  Y. Zhang, C. Papasian, H. Deng. Alteration of vitamin D metabolic enzymes expression and calcium transporters abundance in kidney involved in type 1 diabetes-induced bone loss. (The 5th International Conference on Osteoporosis and Bone Research, October 2010, Invited oral presentation based on competitive basis)

14.  H. He, S. Lei, F. Zhang, J. Li, Y. Liu, Q. Tian, H. Deng. Pathway Pathway-based genome-wide association analysis identified the biological importance of pyrimidine metabolism pathway contributing to osteoporosis. (The 5th International Conference on Osteoporosis and Bone Research, October 2010, Invited oral presentation based on competitive basis)

15.  S. Lei, Y. Guo, T. Yang, H. Shen, X. Xu, S. Dong, Y. Liu, Y. Liu, H. Deng. Genetic Association Study of Common Mitochondrial DNA Variants in Osteoporosis. (The 32st ASBMR Annual Meeting, October 2010, #SA0172)

16.  F. Deng, X. Xu, Y. Liu, H. Shen, S. Lei, J. Li, Y. Guo, T. Yang, L. Zhao, H. Deng. Genome-wide Association Study for Femoral Neck Bone Geometry. (The 32st ASBMR Annual Meeting, October 2010, #MO0162)

17.  J. Zhang, J. Li, H. Deng. Pathway Analysis for Multiple Traits in Genome-Wide Association Studies. (The ASHG Annual Meeting, November 2010)

18.  N. Yu, T. Xu, Y. Cheng, Y. Pei, L. Zhang, J. Chen, H. Liu, J. Li, R. Kirk, Q. Tian, P. Yu, J. Hamilton, Y. Liu, H. Deng Association Analyses of Mitochondrial Genes Polymorphisms with Femoral Neck Compression Strength Index. (The ASHG Annual Meeting, November 2010)

19.  Y. Cheng, T. Xu, T. Yang, Y. Pei, L. Zhang, N. Yu, H. Liu, J. Li, K. Redger, Q. Tian, P. Yu, J. Hamilton, C. Papasian, Y. Liu, H. Zhou, H. Deng. Genome-wide Copy-Number-Variation Analysis Identified the DOK6 Gene to Be Associated with Obesity in Chinese. (The ASHG Annual Meeting, November 2010)

20.  H. Deng, X. Li, L. Tan, X. Liu, S. Lei, X. Chen. Bivariate Genome-Wide Association Analyses for Obesity and Osteoporosis in Chinese. (The ASHG Annual Meeting, November 2010)

21.  T. Xu, Y. Cheng, Y. Pei, L. Zhang, N. Yu, T. Yang, J. Chen, X. Xu, S. Dong, H. Liu, J. Li, J. Hamilton, Y. Liu, H. Deng. A genome-wide association scan identified sex-specific genes for obesity in Chinese. (The ASHG Annual Meeting, November 2010)

22.  J. Chen, Y. Liu, Y. Pei, J. Li, J. Hamilton, H. Deng. Biological Pathway-based Genome-wide Association Analysis Identified the Importance of Inflam Pathway for Femoral Neck Bone Geometry in Chinese males. (The ASHG Annual Meeting, November 2010)

23.  Y. Pei, L. Zhang, C. Papasian, H. Deng. Alternative Grouping Strategies Improve Association Power of Detecting Rare Variants for Complex Diseases. (The ASHG Annual Meeting, November 2010)

24.  L. Zhang, Y. Pei, J. Li, C. Papasian, H. Deng. Improved Detection of Rare Genetic Variants for Diseases. (The ASHG Annual Meeting, November 2010)

25.  Y. Zhang, Y. Liu, Y. Guo, X. Liu, X. Xu, Y. Guo, Y. Chen, F. Zhang, F. Pan, X. Zhu, H. Deng. Pathway-based association analyses identified TRAIL pathway for osteoporotic fractures. (The 5th International Conference on Osteoporosis and Bone Research, October 2010)

26.  L. Sun, L. Tan, X. Li, H. Deng. Bivariate genome-wide association analyses for appendicular lean mass and bone geometry in Chinese. (The 5th International Conference on Osteoporosis and Bone Research, October 2010)

27.  F. Yin, S. Lei, X. Li, H. Shen, Y. Liu, Y. Liu, J. Li, Q. Tian, Y. Pei, H. Deng. A copy number variation at 7q34 may be associated with compression strength index in Chinese populations. (The 5th International Conference on Osteoporosis and Bone Research, October 2010)

28.  T. Yang, Y. Guo, L. Zhang, Q. Tian, H. Yan, C. Papasian, R. Recker, H. Deng. Runs of homozygosity identify a recessive locus 12q21.31 for human adult height. (The 5th International Conference on Osteoporosis and Bone Research, October 2010)

29.  Q. Liu, S. Lei, X. Li, X. Chen, J. Li, Y. Pei, H. Deng. Pathway-based genome-wide association analysis identified the importance of RHO pathway for height in Chinese. (The 5th International Conference on Osteoporosis and Bone Research, October 2010)

30.  L. Zhang, H. Hu, Y. Zheng, Y. Liu, J. Li, Q. Xu, H. Deng. FAM3C gene variant is associated with BMD in two Caucasian populations. (The 5th International Conference on Osteoporosis and Bone Research, October 2010)

31.  Y. Guo, T. Yang, S. Lei, H. Shen, X. Xu, S. Dong, H. Deng. Genetic association study of common mitochondrial DNA variants in osteoporosis. (The 5th International Conference on Osteoporosis and Bone Research, October 2010)

32.  R. Hai, X. Liu, Y. zhang, Y. Lin, R. Shao, H. Deng. An epidemiological investigation of sarcopenia in the Chinese population. (The 5th International Conference on Osteoporosis and Bone Research, October 2010)

33.  X. Liu, Y. Liu, H. Yan, H. Deng. GWAS identified critical mutations in the TRHR gene for modulation of lean body mass. (The 5th International Conference on Osteoporosis and Bone Research, October 2010)

34.  X. Chen, L. Tan, R. Liu, S. Dong, H. Deng. Association study on bone mineral density with SNPs at the regions of 2q24.3, 5q21, 7p21.2 and 13q21.1 in Chinese population. (The 5th International Conference on Osteoporosis and Bone Research, October 2010)


2011 Posters and Oral Presentations

1.  F. Deng, S. Lei, Y. Zhang, Y. Zhang, Y. Zheng, L. Zhang, R. Pan, L. Wang, Q. Tian, H. Shen, M. Zhao, W. Lundberg, Y. Liu, C. Papasian, H. Deng. Peripheral Blood Monocyte-Expressed Anxa2 Gene is Involved in Pathogenesis of Osteoporosis in Humans. (ASBMR Annual Meeting, September  2011, #1174, concurrent oral, invited oral presentation based on competitive basis)

2.  X. Xu, Y. Zhou, F. Bu, A. Ye, B. Zhou, R. Recker, J. Lappe, L.J. Zhao. DNA Methylation Levels of CYP2R1 and CYP24A1 predict vitamin D dose-response variation, (ASBMR Annual Meeting, September  2011, invited oral poster presentation based on competitive basis)

3.  T. Yang, Y. Guo, H. Shen, J. Li, Q. Tian, Y. Liu, H. Deng. A Genome-wide Association Analyses of Gene-gene Interactions for Osteoporosis susceptibility. (ASBMR Annual Meeting, September  2011)

4.  F. Zhao, T.  Yang, Y. Guo, H. Shen, Q. Tian, H. Deng. A Genome-wide Screen of Gene-Gene Interactions for Osteoporosis Susceptibility. (The 12th International Congress of Human Genetics (ICHG) and the 61st ASHG Annual Meeting, October 2011)

5.  C. Xu, Q. Tian, J. Li, H. Deng. A relational database for next-generation sequencing data. (The 12th International Congress of Human Genetics (ICHG) and the 61st ASHG Annual Meeting, October 2011)

6.  J. Li, L. Zhang, H. Hu, Y. Liu, P. Yu, F. Zhang, T. Yang, Q. Tian, Y. Zheng, Y. Guo, H. Deng. A Replication Study of Two Genetic Variants for Bone Mineral Density Variation in Caucasians. (The 12th International Congress of Human Genetics (ICHG) and the 61st ASHG Annual Meeting, October 2011)

7.  J. Zhang, H. Shen, J. Li, C. Xu, Y. Jiang, Z. Wu, F. Zhao, L. Liao, Q. Tian, C. Papasian, H. Deng. Comprehensive Characterization of Human Genome Variation by High Coverage Whole-genome Sequencing of Forty Four Caucasians. (The 12th International Congress of Human Genetics (ICHG) and the 61st ASHG Annual Meeting, October 2011)

8.  H. Deng, F. Deng, S. Lei, Y. Zhang, Y. Zhang, Y. Zheng, L. Zhang, R. Pan, L. Wang, Q. Tian, H. Shen, M. Zhao, Y. Lundberg, Y. Liu, C. Papasian. Peripheral Blood Monocyte-Expressed Anxa2 Gene Is Involved in Pathogenesis of Osteoporosis in Humans. (The 12th International Congress of Human Genetics (ICHG) and the 61st ASHG Annual Meeting, October 2011)

9.  C. Qiu, H. Shen, J. Li, H. Deng. Genome-wide DNA Methylation Analysis for Osteoporosis Risk. (The 12th International Congress of Human Genetics (ICHG) and the 61st ASHG Annual Meeting, October 2011)

10.  H. Shen, Y. Chen, T. Xu, C. Yi, Y. Liu, H. Deng. Genome-wide gene expression study of peripheral blood monocytes for osteoporosis. (The 12th International Congress of Human Genetics (ICHG) and the 61st ASHG Annual Meeting, October 2011)


Training and Mentoring

Junior faculties of the team have received direct and close supervision from the senior investigators of the SCOR on both scientific research and research administration. Most of the junior faculties have submitted NIH grant applications (R01, R21, or R03) as independent PIs. Some of these NIH grant applications are successfully awarded. For example, Dr. Yaozhong Liu (PI of Project 2) was awarded an NIH grant (1RC2DE020756) for genome-wide association study of periodontitis.

Partially supported by the funding and research publications from this SCOR, two of the SCOR key personnel, Drs. Yong-Jun Liu and Yao-Zhong Liu, were recently promoted to Associate Professor with tenure at Tulane University.  

The postdoctoral fellows, graduate students and visiting scholars are receiving close and direct supervision/mentoring from their supervisors. Most of them have submitted or are preparing scientific papers as the first authors or co-authors, as reflected by the publications in the current fiscal years. Some trainees received honors and awards for their excellent research related to this SCOR. The following are some examples of the awards our trainees have received. 

Trainee honors and awards:

1.  Han Yan (Ph. D. student). Scholarship for the 2007 Summer Institute in Statistical Genetics at Washington University (Seattle). (2007)                                                                     

2.  Xiao-Gang Liu (Ph. D. student). Scholarship for the 2007 Summer Institute in Statistical Genetics at Washington University (Seattle). (2007)                                                     

3.   Liang Wang (Ph. D. student). Scholarship for the 2007 Summer Institute in Statistical Genetics at Washington University (Seattle). (2007)                                                     

4.  Peng Xiao (Ph. D. student). Scholarship for the 2007 Summer Institute in Statistical Genetics at Washington University (Seattle). (2007)                                                                     

5.  Dong-Hai Xiong (Ph. D. student). Scholarship for the 2007 Summer Institute in Statistical Genetics at Washington University (Seattle). (2007)                                                     

6.  Jian-Feng Liu (Postdoc. Fellow). Scholarship for the 2007 Summer Institute in Statistical Genetics at Washingto n University (Seattle). (2007)                                                     

7.  Ji-Gang Zhang (Postdoc. Fellow). Scholarship for the 2007 Summer Institute in Statistical Genetics at Washington University (Seattle). (2007)                                                           

8.  Xiao-Gang Liu (M.D., Ph. D. student)      Fellowship to attend the 2nd Annual Endocrine Fellows Foundation Forum on Metabolic Bone Diseases on September 14-15, 2007 at the Sheraton Waikiki Hotel in Honolulu, HI, Endocrine Fellow Foundation.

9.  Yang Fang Duo (Ph. D. Student). 13th Summer Institute in Statistical Genetics, University of Washington, Seattle. June, 2008                                                                                         

10.  Lan-Juan Zhao (Ph. D.) Yong Investigator Award ASBMR Meeting on New Frontiers in Skeletal Research: Bone, Fat and Brain Connections. Washington DC, April 2009, for the abstract Powerful Bivariate Genome-wide Association Analyses Identified the BIG2 Gene Influencing both Obesity and Osteoporosis Phenotypes                                             

11.  Lei Zhang (Ph. D. candidate) Fellowship, Summer Institute of Statistical Genetics, Seattle, university of Washington, June 2009.                                                                                              

12.  Yu-Fan Pei (Ph. D. candidate) Fellowship, Summer Institute of Statistical Genetics, Seattle, university of Washington, June 2009.                                                                                              

13.  Guo, Yan (Ph. D. candidate) Fellowship, Summer Institute of Statistical Genetics, Seattle, university of Washington, June 2009.                                                                                              

14.  Yang, TieLin (Ph. D. candidate) Fellowship, Summer Institute of Statistical Genetics, Seattle, university of Washington, June 2009.                                                                                              

15.  Guo, Yan (Ph. D. candidate) Scholarship to attend 50th Annual Short Course in Jackson Laboratory, summer, 2009.                                                                                                   

16.  Yang, TL (Ph. D. candidate) Scholarship to attend 50th Annual Short Course in Jackson Laboratory, summer, 2009.                                                                                                   

17.  Peng Xiao (Ph. D.) 2009 ASBMR (Denver, Sept 11-16, 2009) Young Investigator Award for the abstract presentation MicroRNA Profiling Study in Human Circulating Monocytes Identified the Significance of miR-151 in the Etiology of Osteoporosis                                               

18.  Yan Guo (Ph. D.) 2009 ASBMR (Denver, Sept 11-16, 2009) Shun HaradaYoung Investigator Award for the abstract presentation PTH and IL21R May Underlie Variation of Femoral Neck Bone Mineral Density as Suggested by a Genome-wide Association Study            

19.  Fengxiao Bu, 2009 ASBMR (Denver, Sept 11-16, 2009 Young Investigator Award for the abstract presentation Powerful Bivariate Genome-wide Association Analyses and Follow-up Replication Studies Identified Several Pleiotropic Genes for both Obesity and Femoral Neck Geometry          

20.  Xiao Gang Liu, M. D., Ph. D. (former Ph. D. student, assistant professor at Hunan Normal University) Association studies of MTHFR and TRHR genes with sarcopenia in Chinese.Young Investigator Research Award, Chinese National Science Foundation. 1/1/2010-12/31/2012                                                                 

21.  Xu Chao (M. Sc. Visiting student) Scholarship to attend 15th summer institute of statistical genetics, university of Washington, Seattle, June, 2010                                              

22.  Lei Zhang (Ph. D. candidate) Award for Outstanding Oral Presentation of Research, 2010 Internaitonal Symposium of Analyses for Compelex Diseases. Fudan University, ShangHai, China, June, 2010                                                                                                                             

23.  Na Yu, M. D. Fellowship for the EFF/ASBMR Fourth Fellows Forum on Metabolic Bone Diseases Symposium of Analyses for Compelex Diseases. Fudan University, ShangHai, China, and hotel accommodation                                                                                                           

24.  Yan Guo, Ph. D., Genetic association study of PTH and IL21R genes with osteoporosis, Chinese National Science Foundation. 81000363, 2011.01-2013.12,                         

25.  Tie-Ling Yang, The Association Analyses between Copy Number Variation and Obesity, Chinese National Science Foundation. 31000554, 2011.01-2013.12,                         

26.  Shu-Feng Lei, Ph. D., The regulation mechanism of polymorphisms at miRNA target sites on osteoporosis (National Science Foundation 31071097), 2011.01-2013.12,    .

27.  Xi Li, Ph. D. candidate. Genome-wide bivariate association study suggested the KIAA1383 gene and FAM172A gene affecting both obesity and osteoporosis. International Conference On Osteoporosis and Bone Research, Shenzhen, China, October 28-31, 2010. Web Jee Yong Investigator Award                                                                                                                        

28.  Na Yu, M. D., Ph. D., Fellowship to EFF/ASBMR Fourth Fellows Forum on Metabolic Bone Diseases Toronto, Ontario, Canada , October 13-14, 2010, full support for travel, registration, hotel                                                                                                                                                          

29.  Yan Zhang, Web Jee Young Investigator Award, International Conference of Bone Research 2010, Shenzhen, Oct 28-31, 2010 for the study "Alteration of vitamin D metabolic enzymes expression and calcium transporters abundance in kidney involved in type 1 diabetes-induced bone loss"

30.  Xi Li, Web Jee Young Investigator Award, International Conference of Bone Research 2010, Shenzhen, Oct 28-31, 2010 for the study "Genome-wide bivariate association study suggested the DDX6 gene affecting both obesity and osteoporosis."

31.  Rong Pan, Web Jee Young Investigator Award, International Conference of Bone Research 2010, Shenzhen, Oct 28-31, 2010 for the study "Association analyses suggest the effects of RANK and RANKL on age at menarche in Chinese."

32.  Hao He, Web Jee Young Investigator Award, International Conference of Bone Research 2010, Shenzhen, Oct 28-31, 2010 for the study "Pathway-based Genome-Wide Association Analysis Identified the Biological Importance of Pyrimidine Metabolism Pathway Contributing to Osteoporosis"

33.  Hongbin Liu, a graduate student, received Young Investigator Award in 2010 Annual Meeting of American Society for Bone and Mineral Research (ASBMR). October 15-19, 2010. Project: Contributions of PTH-mediator CREB to Postnatal Bone Mass in Human and Mouse through Regulation of Osteoblast Function.

34.  Hongbin Liu, a graduate student, received Webster Jee Young Investigator Award in 2010 International Conference on Osteoporosis and Bone research, Nov. 28-31, 2010. Project: Involvement of microtubule dynamics in bone mass by regulating both osteoblast and osteoclast function, -- Osteopenic phenotype of stathmin deficiency in mice.

35.  Kristin Burns, a UMKC medical student who is under supervision of Dr. Yongjun, received Sarah Morrison Research Fellowship award from UMKC School of Medicine.  Project: Evaluation of Bending Strength Index of the Femoral Neck in Caucasians, African-Americans, and Chinese.

36.  Dr. Jigang Zhang is a recipient of a 2011 ASHG Trainee Research Semifinalist Award. His abstract was reviewed by the Scientific Program Committee and was selected as one of 79 out of nearly 450 trainee submissions.

37.  Dr. Fei-Yan Deng has received "2011 ASBMR Young Investigator Travel Grant" for her outstanding research on "Peripheral Blood Monocyte-Expressed Anxa2 Gene Is Involved in Pathogenesis of Osteoporosis in Humans."

38.   Dr. Hongbin Liu has received "2011 ASBMR Young Investigator Travel Grant" for his outstanding research on "Microtubule contribution to osteoclastogenesis, -- low bone mass phenotype of stathmin deficient mice."

39.  Xiaojing Xu has received "2011 ASBMR Young Investigator Travel Grant" for her outstanding research on "DNA methylation levels of CYP2R1 and CYP24A1 predict vitamin D dose-response variation."

40.  Yao-Zhong Liu, Hong-Wen Deng, Genome-wide association study of Periodontitis, NIH 1RC2DE020756-01, 9/25/2009-8/31/2011.


New, inter-disciplinary collaborations

Anchored on this SCOR, Dr. Hong-Wen Deng and all other key investigators have developed a new, multi- and inter-disciplinary research center, namely, the Center for Bioinformatics and Genomics at the new study site, Tulane University School of Public Health and Tropical Medicine. 

Partially supported by this SCOR project, the center is currently staffed with 1 Endowed Chairs, 1 full professor, 4 associate professors, 4 tenure track assistant professors, 2 research assistant professors, and ~40 postdoctoral researchers, graduate students, visiting scholars, research coordinators, technicians, and database managers, who have expertise in diverse study areas such as the statistical genetics, molecular and cellular genetics, quantitative and population genetics, and bioinformatics. In addition, the center is recruiting 4 new tenure track assistant/associate professor during the next 1-2 years to complement and strengthen the current research in the center. One of the associate professors is from another school of Tulane University in the Department of Biomedical Engineering in School of Science and Engineering. One of the tenure track assistant professors is from Department of Epidemiology, and one tenure track professor is from another university in the Department of Computer Sciences in University of New Orleans. All the other faculty, while having primary appointment in the Department of Biostatistics and Bioinformatics, hold joint/adjunct appointments in different departments (Medicine, Orthopedic Surgery, Biochemistry, Molecular and Cell Biology, Biomedical Engineering) of two other schools (School of Medicine and School of Science and Engineering) at Tulane University. In addition, the center is recruiting 4 new faculties, to strengthen and complement the research of current faculty in perspective of multi- and inter-disciplinary research and collaboration. These faculty and staff are engaged in research ranging from basic in vitro cell line studies, in vivo mice studies, human clinical and translational research, to clinical patient care in musculoskeletal diseases and related health problems.

Development of this center will greatly stimulate the inter-disciplinary collaborative research for human genetics/genomics and bioinformatics within Tulane University School of Public Health and Tropical Medicine, across different departments and schools of Tulane University. We are also seeking collaboration with other universities, institutions, and clinics and hospitals around New Orleans area.


Workshops, seminars, and presentations

We have organized a series of seminars and presentations at UMKC (the former home institute) and other institutes in the Kansas City area to exchange ideas and promote collaborations. At the new study site, Tulane University, we are organizing seminar/presentation series at the Center for Bioinformatics and Genomics. Weekly presentations are scheduled for the SCOR investigators to present study results, exchange opinions, and discuss new ideas. We have also invited a number of outside speakers who are the experts in the field to give talks in the center.

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Department of Biostatistics, 1440 Canal Street, Suite 2001, New Orleans, LA 70112, 504-988-5164 kbranley@tulane.edu