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 Ming Zhao  

Ming Zhao, MD PhD
Adjunct Associate Professor
Departments of Biostatistics and Bioinformatics,
Tulane University School of Public Health & Tropical Medicine
1440 Canal Street, Suite 2001
New Orleans, LA 70112-2705

  



Research Interests:

Cellular and molecular biology of skeleton, genetically altered mouse models for investigating pahtphysiological mechanisms of bone formation in osteoporosis 

 

Professional Experience:

  • "The Annual Research Award", Academy of Military Medical Sciences, China, 1992
  • "Excellent Medical Research of Young Investigator", National Army Award, China, 1993
  • "National Army Award in Science and Technology", China, 1994
  • "National Army Award in Science and Technology", China, 1996
  • "National Zhengji Biochemistry Award", Zhengji Biochemistry Foundation, China, 1996
  • "Elitist Young Scientist Award", China, 1996
  • "Young Investigator Award", American Society for Bone and Mineral Research, USA, 1999
  • "Young Investigator Award", Texas Mineralized Tissues Society, USA, 2000
  • "Travel Award", The 1st Joint Meeting of the International Bone and Mineral Society and Japanese Society for Bone and Mineral Research meeting, Japan, 2003
  • "R03 grant – Gli2 regulation of BMP2 expression in aging", NIH/NIA, 2004
  • "K01 Award – Mechanism of Gli2 transactivation of BMP2 in osteoblasts", NIH/NIAMS, 2005

Educational Background:

 

  • PhD, Molecular Biology and Biochemistry, Academy of Military Medical Sciences, China, 1993
  • MS, Pharmacology, Academy of Military Medical Sciences, China, 1989
  • MD, Medicine, Hebei Medical University, China, 1983

Selected Publications: 

Mundy GR, Garrett IR, Harris SE, Chan J, Chen D, Rossini G, Boyce B, Zhao M, Gutierrez G.  Stimulation of Bone Formation in vitro and in Rodents by Statins.  Science, 286(3):1946-1949, 1999.

Kimura M, Zhao M, Zellin G, Linde A. Bone-Inductive Efficacy of Recombinant Human BMP-2 Expressed in E. coli. An Experimental Study in Rat Mandibular Defects. Scand J Plast Reconstr Hand Surg, 34(4):289-299, 2000.

Chen D, Zhao M, Oyajobi BO, Mundy, G.R. Update in Bone Cell Biology.  In: Osteoporosis and Bone Biology, Compston, J., Ralston S.H., (eds), International Medical Press, London, p29-42, 2000.

Mundy GR, Chen D, Zhao M, Dallas S, Xu C, Harris SE. Growth Regulatory Factors and Bone.  In: Reviews in Endocrine and Metabolic Disorders, LeRoith, D. (eds), 2:p105-115, 2001.

Zhao M, Harris SE, Horn D, Geng ZP, Nishimura R, Mundy GR, Chen D.  Bone Morphogenetic Protein Recaptor Signaling Is Necessary for Normal Murine Postnatal Bone Formation. J Cell Biology, 157(6):1049-1060, 2002.

Zhao M, Chen D. E.coli-Expressed rhBMP-2 and Its Application.  In: Advances in Skeletal Reconstruction Using BMPs, Lindholm, T.S. (eds), World Scientific Publishing, London, p1-18, 2002.

Oyajobi BO, Franchin D, Williams PJ, Gupta A, Munoz S, Zhao M, Chen D, Sherry BA, Mundy,GR. Dual effects of macrophage inflammatory protein-1? on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease.  Blood, 102(1): 311-319, 2003.

Garrett IR, Chen D, Gutierrez G, Zhao M, Escobedo A, Rossini G, Harris SE, Gallwitz W, Kim KB, Hu S, Crews CM, Mundy GR.  Selective Inhibitors of the Chymotrypsin-like Activity of the Osteoblast Proteasome are Potent Stimulators of Bone Formation in Vivo and In Vitro. J. Clinical Investigation, 111(11): 1771-1782, 2003.

Feng JQ, Xing LP, Zhang JH, Zhao M, Horn D, Chan J, Boyce BF, Harris SE, Mundy GR, Chen D. NF-kB specifically activates BMP-2 gene expression in growth plate chondrocytes in vivo and in a chondrocyte cell line in vitro. J. Biol. Chem. 278(31): 29130-29135, 2003.

Zhao M, Qiao M, Oyajobi BO, Mundy GR, Chen D.  E3 Ubiquitin ligase Smurf1 mediates Cbfa1 degradation and plays a specific role in osteoblast differentiation. J. Biol. Chem, 278(30): 27939-27944, 2003.

Chen D, Zhao M, Mundy GR. Bone Morphogenetic Proteins.  In: Encyclopedia of Homones, Henry, H.L., Norman, A.W. (eds), Elsevier Science, San Diego, USA, p205-209, 2003.

Zhao M, Qiao M, Harris SE, Oyajobi BO, Mundy GR, Chen D.  Smurf1 inhibits osteoblast differentiation and bone formation in vitro and in vivo. J. Biol. Chem, 279(13): 12854-12859, 2004.

Chen D, Zhao M, Mundy GR.  Bone Morphogenetic Proteins. In Growth Factors, A Burgess (ed).  Taylor and Francis Publishers, 22(4):233-241, 2004.

Chen D, Zhao M, Harris SE, Mi ZH.  Signal Transduction and Biological Functions of Bone Morphogenetic Proteins.  Frontiers in Bioscience, 9(1): 349-358, 2004.

Sterling JA, Oyajobi BO, Grubbs B, Padalecki SS, Munoz SA, Gupta A, Story B, Zhao M, Mundy GR.  The Hedgehog Signaling Molecule Gli2 Induces PTHrP Expression and Osteolysis In Metastatis Human Breast Cancer Cells.  Cancer Research, 66(15):7548-53, 2006.

Zhao M, Qiao M, Harris SE, Chen D, Oyajobi BO, Mundy GR.  The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling.  Mol Cell Biol.  26(16):6197-208, 2006.

Oyajobi BO, Garrett IR, Gupta A, Flores A, Esparza J, Munoz S, Zhao M, Mundy GR.  Stimulation of New Bone Formation by the Proteasome Inhibitor, Bortezomib: Implications for Myeloma Bone Disease. British J Haematology.  139:434-438, 2007.

Su JL, Yang CY, Zhao M, Kuo ML, Yen ML.  Forkhead Proteins Are Critical for Bone Morphogenetic Protein-2 Regulation and Anti-tumor Activity of Resveratrol. J Biol Chem. 282:19385-19398, 2007.

Zhao M, Mundy GR, Oyajobi BO, Padalecki SS, Sterling JA, Elefterious F, Gutierrez G. Bone Morphogenetic Proteins  in cytokines and bone remodeling of Osteoporosis, Marcus B, Kelsey J, Feldman D. Academic Press, New York, 2nd edit, 503-509, 2008.

Zhao M, Ko SY, Liu JH, Chen D, Wang BL, Harris SE, Oyajobi BO, Mundy GR.  Inhibition of microtubule assembly in osteoblasts stimulates BMP-2 expression and bone formation through the transcription factor Gli2.  Mol Cell Biol.  29(5): 1291-1305, 2009.

Li W, Yu B, Li M, Sun D, Hu Y, Zhao M, Cui CB, Hou S. NEMO-binding domain peptide promotes osteoblast differentiation impaired by tumor necrosis factor alpha. Biochem Biophys Res Commun. 391(2):1228-1233, 2010.

Su JL, Chiou Jean, Tang CH, Chen PS, Zhao M, Chang YW, Chien MS, Kuo ML, Yen ML.  CYR61 regulates BMP2–dependent osteoblast differentiation through αvβ3 integrin/ILK/ERK pathway. J Biol Chem.  2010.

Deng FY, Lei SF, Zhang Y, Zhang YL, Zheng YP, Zhang LS, Pan R, Wang L, Tian Q, Shen H, Zhao M, Lundberg YW, Liu YZ, Papasian CJ, Deng HW. 2011. Peripheral blood monocyte-expressed ANXA2 gene is involved in pathogenesis of osteoporosis in humans. Mol Cell Proteomics. 2011 Nov; 10(11):M111.011700. Epub 2011 Aug 4.

Thompson AM, Zhang Y, Tong W, Xu T, Chen J, Zhao L, Kelly TN, Chen CS, Bazzano LA, He J. Association of obesity and biomarkers of inflammation and endothelial dysfunction in adults in Inner Mongolia, China. Int J Cardiol. 2011 Aug 4;150(3):247-52. Epub 2010 May 1.

 

Level of Instruction:

graduate  

[ View all Biostatistics & Bioinformatics Faculty ]

 

 
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Department of Biostatistics, 1440 Canal Street, Suite 2001, New Orleans, LA 70112, 504-988-5164 kbranley@tulane.edu