Biostatistics and Bioinformatics

Research Interests:

Population Genetics, Computational Statistics, Transcriptomics, Bioinformatics

Memberships:

• Member, American Heart Association (Arteriosclerosis Thrombosis and Vascular Biology Council)
• Member, American Society of Human Genetics
• Member, American Stroke Association
• Member, Mathematical Association of America
• Member, The Association for Computing Machinery
• Member, The IEEE Computer Society

Educational Background:

• Postdoc, Statistical and Population Genetics, Harvard University, USA, 2002
• M.S., Computer Science, Northeastern University, USA, 2004
• Sc.D., Biological Sciences, Harvard University, USA, 1998
• B.S., Biological Sciences, University of Science and Technology of China, 1992

Selected Publications:

Chan KH, Niu T, Ma Y, You NC, Song Y, Sobel EM, Hsu YH, Balasubramanian R, Qiao Y, Tinker L, Liu S. Common Genetic Variants in Peroxisome Proliferator-Activated Receptor-γ (PPARG) and Type 2 Diabetes Risk Among Women's Health Initiative Postmenopausal Women. J Clin Endocrinol Metab. 2013 Feb 5.

Zhang Y, Niu T. 2010. Chapter 2. Haplotype Structure. In: Handbook on Analyzing Human Genetic Data: Computational Approaches and Software. Lin S, Zhao H (Eds.), Springer-Verlag, 25-80.

Rosen CJ, Niu T. Chapter 49. Insulin-like Growth Factors and the IGF Binding Proteins: Implications for Bone Biology. In: Principles of Bone Biology, Two-Volume Set. Volume 1-2, 3rd Ed. Bilezikian JP, Raisz LG, Nelson D, Martin TJ (Eds.), Academic Press, 2008, 1061-1086.

Hong X, Niu T, Chen C, Wang B, Venners SA, Fang Z, Xu X. 2007. Familial aggregation of forearm bone mineral density in Chinese. Eur J Epidemiol 22:335-41.

Hsu YH, Xu X, Terwedow HA, Niu T, Hong X, Wu D, Wang L, Brain JD, Bouxsein ML, Cummings SR, Rosen CJ, Xu X. 2007. Large-scale genome-wide linkage analysis for loci linked to BMD at different skeletal sites in extreme selected sibships. J Bone Mineral Res 22:184-94.

Baclawski K, Niu T. Ontologies for Computational Biology. MIT Press, 2006.

Zhang Y, Niu T, Liu JS. 2006. A coalescence-guided hierarchical Bayesian method for haplotype inference. Am J Hum Genet 79:313-22.

Hsu YH, Niu T, Terwedow HA, Xu X, Feng Y, Li Z, Brain JD, Rosen CJ, Laird N, Xu X. 2006. Variation In Genes Involved In The RANKL/RANK/OPG Bone Remodeling Pathway are Associated with Bone Mineral Density at Different Skeletal Sites in Men. Hum Genet 118:568-77.

Niu T, Rosen CJ. 2005. The Insulin-Like Growth Factor-I gene and Osteoporosis: A Critical Appraisal. Gene 361:38-56.

Lu X, Niu T, Liu JS. 2003. Haplotype Information and Linkage Disequilibrium Mapping. Genome Res;13:2112-7.

Kang H, Qin ZS, Niu T, Liu JS. 2004. Incorporating Genotyping Uncertainty in Haplotype Inference for Single-Nucleotide Polymorphisms. Am J Hum Genet 74:495-510.

Niu T, Hu Z. 2004. SNPicker: A Graphical Tool for Primer Picking in Designing Mutagenic Endonuclease Restriction Assays. Bioinformatics 20:3263-5.

Niu T, Qin ZS, Xu X, Liu JS. 2002. Bayesian Haplotype Inference for Multiple Linked Single Nucleotide Polymorphisms. Am J Hum Genet 70:157-69.

Wang X, Zuckerman B, Pearson C, Kaufman G, Chen C, Wang G, Niu T, Wise P, Bauchner H, Xu X. 2002. Maternal Cigarette Smoking, Metabolic Gene Polymorphism, and Infant Birthweight. JAMA 287:195-202.

Niu T, Struk B, Lindpaintner K. 2001. Statistical Considerations for Genome-Wide Scans: Design and Application of a Novel Software Package POLYMORPHISM. Hum Hered 52:102-9.

Niu T, Chen C, Cordell H, Yang J, Wang B, Wang Z, Fang Z, Schork NJ, Rosen CJ, Xu X. 1999. A Genome-Wide Scan for Loci Linked to Forearm Bone Mineral Density. Hum Genet 104:226-33.

Level of Instruction:

Graduate

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