Hui Shen, PhD
Tsai and Kung Professorship in Biostatistics
Department of Biostatistics and Bioinformatics
Tulane University School of Public Health and Tropical Medicine
1440 Canal Street, Suite 2001
New Orleans, LA 70112
Phone: (504) 988-6987
Fax: (504) 988-1706
My research interests are mainly focused on identifying and characterizing genetic and epigenetic variation that affects susceptibility to complex human disorders, such as osteoporosis and sarcopenia. Toward these ends, we are integrating multidisciplinary approaches including genetic epidemiology, functional genomics, epigenomics, proteomics, bioinformatics, and molecular biology. We recently performed an epidgenome-wide MeDIP sequencing (MeDIP-Seq) study to identify differentially methylated regions associated with osteoporosis. We also performed several pioneering sequencing-based projects, including a whole genome sequencing study and an exome sequencing project for osteoporosis in different ethnic groups, using the next-generation sequencing technologies. The successful identification and characterization of genetic and epigenetic variations underlying osteoporosis and sarcopenia will markedly increasing our understanding of disease pathophysiology and may lead to novel and individualized treatment.
- Member, American Society of Human Genetics (ASHG)
- Member, American Society for Bone and Mineral Research (ASBMR)
- Postdoc, Yale University, 2008
- Ph.D.. Creighton University, 2005
- B.S., University of Science and Technology of China, 1999
Shen H, Qiu C, Li J, Tian Q, Deng HW. Characterization of the DNA methylome and its interindividual variation in human peripheral blood monocytes. Epigenomics. 2013 Jun;5(3):255-69.
Liu YZ, Li J, Pan R, Shen H, Tian Q, Zhou Y, Liu YJ, Deng HW. Genome-wide copy number variation association analyses for age at menarche. J Clin Endocrinol Metab. 2012 Nov;97(11):E2133-9. doi: 10.1210/jc.2012-1145.
Deng FY, Dong SS, Xu XH, Liu YJ, Liu YZ, Shen H, Tian Q, Li J, Deng HW. Genome-Wide Association Study Identified UQCC Locus for Spine Bone Size in Humans. Bone. 2012 Nov 30. doi:pii: S8756-3282(12)01390-7. 10.1016/j.bone.2012.11.028.
Yang TL, Guo Y, Shen H, Li J, Glessner JT, Qiu C, Deng FY, Tian Q, Yu P, Liu YZ, Liu YJ, Hakonarson H, Grant SF, Deng HW. Copy Number Variation on Chromosome 10q26.3 for Obesity Identified by a Genome-Wide Study. J Clin Endocrinol Metab. 2012 Nov 21.
Deng HW, Shen H, Xu FH, Deng HY, Conway T, Zhang HT, Recker RR. 2002. Tests of linkage and/or association of genes for vitamin D receptor, osteocalcin, and parathyroid hormone with bone mineral density. J Bone Miner Res. 17:678-86.
Deng HW, Shen H, Xu FH, Deng H, Conway T, Liu YJ, Liu YZ, Li JL, Huang QY, Davies KM, Recker RR. 2003. Several genomic regions potentially containing QTLs for bone size variation were identified in a whole-genome linkage scan. Am J Med Genet. 119:121-31.
Qin YJ, Shen H, Huang QR, Zhao LJ, Zhou Q, Li MX, He JW, Mo XY, Lu JH, Recker RR, Deng HW. 2003. Estrogen receptor alpha gene polymorphisms and peak bone density in Chinese nuclear families. J Bone Miner Res. 18:1028-35.
Huang QY, Shen H, Deng HY, Conway T, Davies KM, Li JL, Recker RR, Deng HW. 2003. Linkage and association of the CA repeat polymorphism of the IL6 gene, obesity-related phenotypes, and bone mineral density (BMD) in two independent Caucasian populations. J Hum Genet. 48:430-437.
Shen H, Recker RR, Deng HW. 2003. Molecular and genetic mechanisms of osteoporosis: implication for treatment. Curr Mol Med. 3:737-757.
Shen H, Zhang YY, Long JR, Xu FH, Liu YZ, Xiao P, Zhao LJ, Xiong DH, Liu YJ, Dvornyk V, Rocha-Sanchez S, Liu PY, Li JL, Conway T, Davies KM, Recker RR, Deng HW. 2004. A genome-wide linkage scan for bone mineral density in an extended sample: evidence for linkage on 11q23 and Xq27. J Med Genet. 41:743-51.
Liu YZ, Xu FH, Shen H, Liu YJ, Zhao LJ, Long JR, Zhang YY, Xiao P, Xiong DH, Dvornyk V, Li JL, Conway T, Davies KM, Recker RR, Deng HW. 2004. Genetic dissection of human stature in a large sample of multiplex pedigrees. Ann Hum Genet. 68:472-88.
Shen H, Liu Y, Liu P, Recker RR, Deng HW. 2005 Nonreplication in genetic studies of complex diseases–lessons learned from studies of osteoporosis and tentative remedies. J Bone Miner Res. 20:365-76.
Jiang DK, Shen H, Li MX, Jiang C, Yang N, Zhu J, Wu Y, Qin YJ, Zhou Q, Deng HW. 2005 No major effect of the insulin-like growth factor I gene on bone mineral density in premenopausal Chinese women. Bone 36:694-9.
Liu YZ, Dvornyk V, Lu Y, Shen H, Lappe JM, Recker RR, Deng HW. 2005. A novel pathophysiological mechanism for osteoporosis suggested by an in vivo gene expression study of circulating monocytes. J Biol Chem. 280:29011-6.
Shen H, Long JR, Xiong DH, Liu YJ, Liu YZ, Xiao P, Zhao LJ, Dvornyk V, Zhang YY, Rocha-Sanchez S, Liu PY, Li JL, Deng HW. 2005. Mapping quantitative trait loci for cross-sectional geometry at the femoral neck. J Bone Miner Res. 20:1973-82.
Xiong DH, Shen H, Xiao P, Guo YF, Long JR, Zhao LJ, Liu YZ, Deng HY, Li JL, Recker RR, Deng HW. 2006. Genome-wide scan identified QTLs underlying femoral neck cross-sectional geometry that are novel studied risk factors of osteoporosis. J Bone Miner Res. 21:424-37
Shen H, Long JR, Liu YZ, Xiao P, Zhao LJ, Xiong DH, Liu YJ, Li JL, Recker RR, Deng HW. 2006. A genomewide scan for quantitative trait loci underlying areal bone size variation in 451 Caucasian families. J Med Genet. 43:873-80.
Guo YF, Shen H, Liu YJ, Wang W, Xiong DH, Xiao P, Liu YZ, Zhao LJ, Recker RR, Deng HW. 2006 Assessment of genetic linkage and parent-of-origin effects on obesity. J Clin Endocrinol Metab. 91:4001-5
Xiong DH, Shen H, Zhao LJ, Xiao P, Yang TL, Guo Y, Wang W, Guo YF, Liu YJ, Recker RR, Deng HW. 2006 Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction. J Bone Miner Res. 21:1678-95.
Yang F*, Shen H*, Jiang H, Deng HW. 2006. On genetic studies of bone loss. J Bone Miner Res. 21:1676-7. (*equal contribution)
Wang L, Liu YJ, Xiao P, Shen H, Deng HY, Papasian CJ, Drees BM, Hamilton JJ, Recker RR, Deng HW. 2007 Chromosome 2q32 May Harbor a QTL Affecting BMD Variation at Different Skeletal Sites. J Bone Miner Res. 22:1672-8
Zhang F, Xiao P, Yang F, Shen H, Xiong DH, Deng HY, Papasian CJ, Drees BM, Hamilton JJ, Recker RR, Deng HW. A whole genome linkage scan for QTLs underlying peak bone mineral density. Osteoporos Int. 2008;19:303-310
Lin Y, Li J, Shen H, Zhang L, Papasian C, Deng HW. 2011. Comparative Studies of de novo Assembly Tools for Next-generation Sequencing Technologies. Bioinformatics. 27(12): 1093
Deng FY, Lei SF, Zhang Y, Zhang YL, Zheng YP, Zhang LS, Pan R, Wang L, Tian Q, Shen H, Zhao M, Lundberg YW, Liu YZ, Papasian CJ, Deng HW. 2011. Peripheral blood monocyte-expressed ANXA2 gene is involved in pathogenesis of osteoporosis in humans. Mol Cell Proteomics. 2011 Nov;10(11):M111.011700. Epub 2011 Aug 4.
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