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Jian Li, PhD
Assistant Professor
Department of Biostatistics and Bioinformatics
Tulane University School of Public Health and Tropical Medicine
1440 Canal Street, Suite 2001
New Orleans, LA 70112
Phone: (504) 988-1675
Fax: (504) 988-1706
jli8@tulane.edu 



Research Focus:

My research is mainly focusing on investigating the relationship between DNA variation and human complex traits. By incorporating tools from genetics, genomics, and statistics, I have been working both on developing new analytical methodology and on conducting analyses on various types of biological data. My recent efforts are centering on genome-wide association studies. Relying on population genetic principals such as structure of linkage equilibrium and facilitating the advanced molecular technologies such as genome-wide SNP arrays and next-generation sequencing data, I am working on dissecting the genetic architecture of human complex diseases such as osteoporosis and obesity.

Another area of interest is to study the genetic variance of DNA sequences. Topics include DNA linkage disequilibrium structure across genome, structural variation such as copy number variation, and ethnic differences in DNA variation across populations such as Caucasian and Asian. 

 

Professional Experience:

Jian Li is a member of American Society of Human Genetics. He has presented his research results in various academic meetings and has been invited as a peer reviewer for various scientific journals such as Genetics, Genetical Research, and Journal of Molecular Psychiatry.

 

Educational Background:

  • B.S., biochemistry and molecular biology, Peking University, 1997
  • M.S., biological sciences, Creighton University, 2000
  • Ph.D., genetics, North Carolina State University, 2005.

Selected Publications: 

Cao B, Liu X, Li J, Liu S, Qi Y, Xiong Z, Zhang A, Wiese T, Fu X, Gu J, Rennie PS, Sartor O, Lee BR, Ip C, Zhao L, Zhang H, Dong Y. 20(S)-protopanaxadiol-aglycone downregulation of the full-length and splice variants of androgen receptor. Int J Cancer. 2013 Mar 15;132(6):1277-87. doi: 10.1002/ijc.27754. Epub 2012 Aug 20.

Kelly TN, Rebholz CM, Gu D, Hixson JE, Rice TK, Cao J, Chen J, Li J, Lu F, Ma J, Mu J, Whelton PK, He J. Analysis of Sex Hormone Genes Reveals Gender Differences in the Genetic Etiology of Blood Pressure Salt Sensitivity: The GenSalt Study. Am J Hypertens. 2013 Feb;26(2):191-200. doi: 10.1093/ajh/hps018. Epub 2012 Dec 28.

Chen J, Zhang JG, Li J, Pei YF, Deng HW. On combining reference data to improve imputation accuracy. PLoS One. 2013;8(1):e55600.

Liu YZ, Li J, Pan R, Shen H, Tian Q, Zhou Y, Liu YJ, Deng HW. Genome-wide copy number variation association analyses for age at menarche. J Clin Endocrinol Metab. 2012 Nov;97(11):E2133-9. doi: 10.1210/jc.2012-1145.

Kelly TN, Gu D, Rao DC, Chen J, Chen J, Cao J, Li J, Lu F, Ma J, Mu J, Whelton PK, He J. Maternal history of hypertension and blood pressure response to potassium intake: the GenSalt Study. Am J Epidemiol. 2012 Oct 1;176 Suppl 7:S55-63.

Zhao Q, Bazzano LA, Cao J, Li J, Chen J, Huang J, Chen J, Kelly TN, Chen CS, Hu D, Ma J, Rice TK, He J, Gu D. Reproducibility of blood pressure response to the cold pressor test: the GenSalt Study. Am J Epidemiol. 2012 Oct 1;176 Suppl 7:S91-8.

Rebholz CM, Gu D, Chen J, Huang JF, Cao J, Chen JC, Li J, Lu F, Mu J, Ma J, Hu D, Ji X, Bazzano LA, Liu D, He J; GenSalt Collaborative Research Group. Physical activity reduces salt sensitivity of blood pressure: the Genetic Epidemiology Network of Salt Sensitivity Study. Am J Epidemiol. 2012 Oct 1;176 Suppl 7:S106-13.

Deng FY, Dong SS, Xu XH, Liu YJ, Liu YZ, Shen H, Tian Q, Li J, Deng HW. Genome-Wide Association Study Identified UQCC Locus for Spine Bone Size in Humans. Bone. 2012 Nov 30. doi:pii: S8756-3282(12)01390-7. 10.1016/j.bone.2012.11.028.

Yang TL, Guo Y, Shen H, Li J, Glessner JT, Qiu C, Deng FY, Tian Q, Yu P, Liu YZ, Liu YJ, Hakonarson H, Grant SF, Deng HW. Copy Number Variation on Chromosome 10q26.3 for Obesity Identified by a Genome-Wide Study. J Clin Endocrinol Metab. 2012 Nov 21. [Epub ahead of print]

Deng HW, Li J, Li JL, Johnson M, Gong G, Davis KM, Recker RR (1998) Change of bone mass in postmenopausal Caucasian women with and without hormone replacement therapy is associated with vitamin D receptor and estrogen receptor genotypes. Hum Genet 103:576-585.

Deng HW, Li JL, Li J, Davies KM, Recker RR (1998) Heterogeneity of bone mineral density across skeletal sites and its clinical implications. J Clin Densitom 1:339-353.

Deng HW, Li J, Li JL (1999) On the experimental design and data analysis of mutation accumulation experiments. Genet Res 73:147-164.

Deng HW, Li J, Li JL, Johnson M, Gong G, Recker RR (1999) Association of VDR and estrogen receptor genotypes with bone mass in postmenopausal Caucasian women: different conclusions with different analyses and the implications. Osteoporos Int 9:499-507.

Deng HW, Li JL, Li J (1999) Recovery of mutations of different sizes from a population sample of DNA sequences under variable mutation rates across sites. Mol Biol Evol 16:1098-1104.  

Li JL, Li J, Deng HW (1999) The effect of overdominance on characterizing deleterious mutations in large natural populations. Genetics 151:895-913.  

Qian SJ, Li J, Gao JM, Guo LD, Ye J (1999) Preparation, purification and identification of sialic acid from Escherichia Coli C-8. Acta Microbiologica Sinica 39:178-180.  

Deng HW, Li J, Li JL, Dowd R, Davies KM, Johnson M, Gong G, Deng H, Recker RR (2000) Association of estrogen receptor-alpha genotypes with body mass index in normal healthy postmenopausal Caucasian women. J Clin Endocrinol Metab 85:2748-2751.

Deng HW, Zhou Y, Recker RR, Johnson ML, Li J (2000) Fragment size difference between multiplex and singleplex PCR products and their practical implications. Biotechniques 29:298-308.  

Li J, Deng HW (2000) Estimation of parameters of deleterious mutations in partial selfing or partial outcrossing populations and in nonequilibrium populations. Genetics 154:1893-1906.

Tao Y, Zeng ZB, Li J, Hartl DL, Laurie CC (2003) Genetic dissection of hybrid incompatibilities between Drosophila simulans and D. mauritiana. II. Mapping hybrid male sterility loci on the third chromosome. Genetics 164:1399-1418.

Moehring AJ, Li J, Schug MD, Smith SG, deAngelis M, Mackay TF, Coyne JA (2004) Quantitative trait loci for sexual isolation between Drosophila simulans and D. mauritiana. Genetics 167:1265-1274.  

Li J, Deng HW (2005) Estimation of the rate and effects of deleterious genomic mutations in finite populations with linkage disequilibrium. Heredity 95:59-68.  

Li J, Wang SC, Zeng ZB (2006) Multiple interval mapping for ordinal traits. Genetics 173: 1649-1663.  

Deng HW, Li J, Pfrender ME, Li JL, Deng HY (2006) Upper limit of the rate and per generation effects of deleterious genomic mutations. Genetical Research 88: 57-65.  

Clark AG, Li J (2007) Conjuring SNPs to detect associations. Nature Genetics 39: 815 - 816.  

Zhang JG, Li J, Deng HW (2008) Class-specific correlations of gene expressions: identification and their effects on clustering analyses. Am J Hum Genet. 83: 269-277.  

Liu YZ, Wilson SG, Wang L, Liu XG, Guo YF, Li J, …, Deng HW (2008) Identification of PLCL1 Gene for Hip Bone Size Variation in Females in a Genome-Wide Association Study. PLoS ONE. 3: e3160.  

Pei YF, Li J, Zhang L, Deng HW (2008) Analyses and Comparison of Accuracy of Different Genotype Imputation Methods. PLoS ONE. 3: e3551.  

Yang RQ, Wang X, Li J, HW Deng (2009) Bayesian robust Analysis for Genetic Architecture of Quantitative Traits. Bioinformatics. 25: 1033-1039.  

Guo YF, Li J, Bonham AJ, Wang YP, Deng HW (2009) Gains in power for exhaustive analyses of haplotypes using variable-sized sliding window strategy: a comparison of association-mapping strategies. Eur J Hum Genet. 17: 785-792.  

Liu, YZ, Pei YF, …, Li J, …, Deng HW (2009) Genome-wide association analyses suggested a novel mechanism for smoking behavior regulated by IL15. Mol Psychiatry. 14: 668-680.  

Lei SH, Tan LJ, …, Li J, …, Deng HW (2009) Genome-wide association study identifies two novel loci containing FLNB and SBF2 genes underlying stature variation. Hum Mol Genet. 18: 1661-1669.  

Zhang JG, Li J, Deng HW (2009) Identifying gene interaction enrichment for gene expression data. PLoS ONE. 4: e8064.  

Zhang L, Pei YF, Li J, Papasian CJ, Deng HW (2009) Univariate/multivariate genome-wide association scans using data from families and unrelated samples. PLoS One. 4: e6502.  

Zhang L, Li J, Pei YF, Liu Y, Deng HW (2009) Tests of association for quantitative traits in nuclear families using principal components to correct for population stratification. Ann Hum Genet. 73: 601-613.  

Zhang L, Bonham AJ, Li J, Pei YF, Chen J, Papasian CJ, Deng HW (2009) Family-based bivariate association tests for quantitative traits. PLoS One. 4: e8133.  

Li J, Yang TL, …, Deng HW (2009) Whole genome distribution and ethnic differentiation of copy number variation in Caucasian and Asian populations. PLoS One. 4: e7958.  

Guo YF, Li J, Chen Y, Zhang LS, Deng HW (2009) A new permutation strategy of pathway-based approach for genome-wide association study. BMC Bioinformatics. 10: 429.  

DE Moor MH, Liu YJ, Boomsma DI, Li J, ..., Deng HW (2009) Genome-Wide Association Study of Exercise Behavior in Dutch and American Adults. Med Sci Sports Exerc. In press.

Pei YF, Zhang L, Li J, Deng HW (2010) Analyses and comparison of imputation-based association methods. PLoS One. 5: e10827.

Zhao LJ, …, Li J, … (2010) Genome-wide association study for femoral neck bone geometry. J Bone Miner Res. 25: 320-329.

Lin Y, Li J,. . . (2011) Comparative Studies of de novo Assembly Tools for Next-generation Sequencing Technologies. Bioinformatics. 27(12): 1093

Li J, Gui YF, Pei Y, Deng HW. The impact of imputation on meta-analysis of genome-wide association studies. PLoS One. 2012;7(3):e34486. Epub 2012 Apr 5.

 

Level of Instruction:

graduate  

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Department of Biostatistics, 1440 Canal Street, Suite 2001, New Orleans, LA 70112, 504-988-5164 kbranley@tulane.edu