With bioinformatic tools, the data are correlated with genome-wide expression profiles (both exon microarray from myoblast strains grown in her lab and ENCODE RNA-seq data) and histone modification and ChIP-seq profiles of transcription factor binding to compare myoblasts, myotubes, and dozens of non-muscle cell types analyzed by identical methods. Molecular genetic studies are used for follow-up of selected drivers of differentiation. This research addresses both DNA methylation (5-methylcytosine) and the newly discovered hydroxymethylation (5-hydroxymethylcytosine) of mammalian DNA as well as normal vs. dystrophic myogenesis (FSHD, facioscapulohumeral muscular dystrophy). In addition, she is studying the DNA epigenetics of human cancer, a field in which her lab played a major pioneering role in the 1980's and 1990's. Currently, she is collaborating with Garth Rausher at the University of Illinois at Chicago in a 5-year breast cancer epigenetics project.